Structural characterization of a series of polymer-protein conjugates for chronic wound treatments

DOI

Polymer-protein conjugates have been designed to deliver an appropriate target growth factor to promote a more rapid healing of chronic wounds, an incredibly important area for the aging population throughout the developing world, costing the health service in Wales alone some £30M/year. Such wounds are characterised by dysfunctional extracellular matrix (ECM) regeneration, and there is evidence that the level of growth factor in the ECM is a key factor. Here, we wish to probe the structure of growth factor - dextrin and growth factor - hyaluronic acid conjugates in order to benchmark the observed biological activity with the structural characteristics of the conjugate.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24032637
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24032637
Provenance
Creator Professor Peter Griffiths; Dr Alison Paul
Publisher ISIS Neutron and Muon Source
Publication Year 2012
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2008-09-23T08:02:05Z
Temporal Coverage End 2009-07-17T11:19:00Z