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Calcium and pH induced changes in silk solutions
Spider silks are known to have outstanding mechanical properties yet there is still much unknown about how the initial structure, storage and transformation of the silk proteins... -
Using Magnetic Contrasts to Establish the Mechanism and Kinetics of Lipid Fli...
In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied... -
SANS Study of the interaction of model wax alcohols with non-ionic surfactant...
The understanding of the plant wax-surfactant interaction process is crucial to the development of more effective pesticide and fungicide formulations, essential for improving... -
Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic lipid bil...
Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug... -
Antibiotic Interactions with models of the Gram negative bacterial outer memb...
Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is... -
Interaction of the nucleic acid, DNA, with a model biomembranes of varying ri...
In this experiment we aim to investigate, using neutron reflectometry in combination with contrast variation, the intermolecular interaction between the nucleic acid, calf... -
Neutron reflectivity studies of the interaction of amphotericin with model ce...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
Interaction between RNA and lipid monolayers
The objective of the suggested study is to reveal the structure formed when short ssRNA molecules (similar to miRNA) interact with lipid monolayers at the air-water interface.... -
Recreating the specific colicin NRa-LPS interaction in a model bacterial out...
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the... -
SANS Study of the interaction of model wax alcohols with non-ionic surfactant...
The understanding of the plant wax-surfactant interaction process is crucial to the development of more effective pesticide and fungicide formulations, essential for improving... -
Structural characterization of a series of polymer-protein conjugates for chr...
Polymer-protein conjugates have been designed to deliver an appropriate target growth factor to promote a more rapid healing of chronic wounds, an incredibly important area for... -
The Interaction of Small Cationic Amphiphillic Antimicrobial Proteins with Fr...
Protein-membranes interactions are fundamentally important to biological function. We have developed advanced models of the Gram negative bacterial outer membrane and have... -
The Kinetics of Ethanol Adsorption into Cholesterol Rich Bilayers
In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed... -
Calcium mediated interaction between siRNA and phospholipid bilayers: the eff...
The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the... -
Head Group charging and anaesthetic Interaction with Model Bilayers
The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers... -
The Interaction of wild-type and mutant Puroindoline B with Model Bacterial M...
Bacterial and fungal infections of cereal crops pose a considerable risk to global food security. Typically plant pathogens are controlled through the use of chemical agents... -
New Approaches to Producing Floating Supported Bilayers
The complex sample environment needed for floating supported bilayers has often led to a need to constantly redevelop the system to improve reproducibility. Here we plan to... -
Floating Bilayers Deposited on Au / Fe Surfaces
There is currly great interest in the use of neutron reflection to study model bilayers. We have produced a model membrane system that is strongly associated with the substrate,... -
Antimicrobial Peptide Binding & Rearrangement in Model Membranes ¿ Building a...
Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering... -
Conformation of di-stearoyl-polyethylene glycol surfactants as enhancers of b...
This proposal relates to the structural studies of Di-stearoyl and di-palmitoyl Polyethylene glycol derivates as a function of the PEG head group at the air-water and the...