318 datasets found

Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key...

This proposal is part of a research programme which is focused on nano-fibres prepared by electrospinning. The programme is centered on developing an understanding of the...

Dendrimers are nanosized macromolecules with hyperbranched structures that are capable of loading all kinds of active agents for biodelivery. They are monodisperse in terms of...

Thermoresponsive gels are widely used for tissue engineering and drug delivery applications. They consist of a thermoresponsive polymer that self-assembles in a 3D network when...

We have developed a new and benign method for the production of cellulose based aerogels, highly porous materials with applications in insulation, drug delivery, gas storage,...

Doxil® is a marketed liposomal formulation containing the anticancer drug doxorubicin. Recently, SAXS measurements have evidenced a crystalline fibrillar structure for the...

In the present study the acidic, anti-inflammatory drug, ibuprofen has been PEGylated using an polyoxyethylene chain of 750 molecular weight. The consequence of this PEGylation...

Short peptide sequences such as KLVFFAE form well defined beta sheet structures. Their further templating through hydrophobic interactions and hydrogen bonding is the principal...

Although microemulsions have been widely investigated as potential drug delivery vehicles, relatively little work has been performed establishing the detailed molecular...

In this proposal we shall explore the nature of electrospun fibres produced from blends of cellulose and polystyrene which we shall use as a model to develop high strength...

Paints are typical formulated products. The paint consists of many different components - pigments, thickeners, surfactants - each of which has a specific function. The physical...

Bowel cancer is the fourth most common cancer in the UK with approximately 41,000 individuals in the UK diagnosed annually. Importantly it is estimated that over half of all...

Dynamic microdomains, resulting from lateral lipid inhomogeneity and patterning within biological membranes, have been implicated in a wide range of critical cellular processes...

Using an enzyme mediated conjugation method we have prepared well-designed protein-polymer conjugates using a model protein, green fluorescent protein (GFP) with...

At the heart of protein¿s aggregation are specific molecular events; and how they are modulated by changes in solvent conditions is key to our understanding and control of...

Human dihydroorotate dehydrogenase (DHODH) is an integral membrane protein found in mitochondria involved in the biosynthesis of pyrimidines. DHODH oxidizes dihydroorotate with...

This proposal forms part of an ongoing project concerning interpenetrating network gels of starch and cellulose being developed towards applications in personal care and...

The aim of this experiment is to characterise several novel ionic liquid ¿ oil and ionic liquid ¿ water microemulsions via SANS prior to their use in the synthesis of metallic...

We hope to explore the self assembly properties of a novel chain end functionalised homopolymer to better understand its structure and enable tuning of its properties to enable...

This proposal aims to investigate the interaction of oxidised cellulose nanofibrils (OCNF) and anionic surfactants, such as sodium laureth sulphate (SLES) and sodium lauroyl...