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Aggregation phenomena inside polymer brushes: lateral structure
We will use off-specular reflectivity to probe the characteristic lateral length-scales in responsive polyelectrolyte brushes grown by surface-initiated ATRP from solid-liquid... -
The role of disulphide bridges in the adsorption of globular proteins at the ...
Following our previous study of adsorption of globular lysozyme and BSA at the oil/water interface by neutron reflection, we continue to explore how unfolding of globular... -
Structural insight into the mechanistic process of permeabilization into mode...
The aim of this study is to try to understand how antimicrobial peptides bind to model lipid monolayers mimicking different cell membrane types. Following our previous work,... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
A comparative NR study of interaction of short designed antimicrobial peptide...
The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial... -
NR study of binding of short antimicrobial alpha-helix peptides with model li...
In this work we explore how our rationally designed peptide amphiphiles bind onto lipid monolayers using neutron reflection combined with deuterium labelling to the lipids,... -
Co-adsorption and competitive adsorption of eggshell membrane polypeptide aga...
In this work we explore how to use neutron reflection to study the interfacial adsorption from a natural eggshell membrane polypeptide at the oil/water interface. We will then... -
Manipulating surface adsorption of SLES surfactants using temperature
Although surfactant detergency is well understood above 30 C, actions of surfactants below 30 C are not well established. In the era of energy saving and environment caring, we... -
Chain Conformations in Monodisperse/Polydiserpse Electrospinning Solutions
Electrospinning is a technique which produces fibres from a polymer solution exposed to an electric field. The technique forms fibres substantially smaller in diameter than a... -
Designing polymer therapeutics to diffuse through mucin
Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key... -
Effect of temperature on the structure of model wax films as studied by neutr...
Cuticular wax films protect plants by mediating water and nutrient transport from the environment. Surfactant is a key ingredient in agrisprays that can promote the uptake of... -
Model biomembrane dendrimer interactions
The objective of the present study is to investigate the interaction between PAMAM dendrimers and solid supported model biomembranes of high fluidity. These membranes consist of... -
Interaction of polypeptide with surfactant: SANS study of solution aggregation
This proposal constitutes part of our ongoing study towards understanding the solution aggregation of collagen based polypeptides and their interactions with model surfactants.... -
Structural characterization of a series of polymer-protein conjugates for chr...
Polymer-protein conjugates have been designed to deliver an appropriate target growth factor to promote a more rapid healing of chronic wounds, an incredibly important area for... -
La dopped EuO
Currently one of the biggest challenges in spintronics is the generation and control of a spin polarized current at room temperature. Spin injection from europium monoxide is of... -
SANS Study of the interaction of model wax alcohols with non-ionic surfactant...
The understanding of the plant wax-surfactant interaction process is crucial to the development of more effective pesticide and fungicide formulations, essential for improving... -
Antimicrobial Mechanisms of Model Biocides via Their Interaction with Lipopol...
The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial... -
Insertion of antimicrobial peptides into phospholipid monolayers at air/liqui...
We have designed a series of cationic peptides with different helix repeats that can kill bacteria but remain benign to mammalian host cells. The selectivity to cell types is... -
SANS Study of the interaction of model wax alcohols with non-ionic surfactant...
The understanding of the plant wax-surfactant interaction process is crucial to the development of more effective pesticide and fungicide formulations, essential for improving... -
NR study of binding of short antimicrobial alpha-helix peptides with model li...
In this work we explore how our rationally designed peptide amphiphiles bind onto lipid monolayers using neutron reflection combined with deuterium labelling to the lipids,...