The objective of the suggested study is to reveal the structure formed when short ssRNA molecules (similar to miRNA) interact with lipid monolayers at the air-water interface. Our previous study using the surface film balance to study the Langmuir monolayers of different lipids, demonstrate that this these short nucleic acids shows a significant different behavior compared to DNA molecules. Using neutron reflectometry important information about the organization and structure of the monolayers can be obtained. Understanding the interaction between short RNA molecules and phospholipids is important for understanding biological function and in the development of gene therapy and other applications in biotechnology and medicine. We suggest to use neutron reflectometry to study the adsorption behavior of short RNA molecules to insoluble monolayers of zwitterionic and cationic lipids.