Interaction between RNA and lipid monolayers

DOI

The objective of the suggested study is to reveal the structure formed when short ssRNA molecules (similar to miRNA) interact with lipid monolayers at the air-water interface. Our previous study using the surface film balance to study the Langmuir monolayers of different lipids, demonstrate that this these short nucleic acids shows a significant different behavior compared to DNA molecules. Using neutron reflectometry important information about the organization and structure of the monolayers can be obtained. Understanding the interaction between short RNA molecules and phospholipids is important for understanding biological function and in the development of gene therapy and other applications in biotechnology and medicine. We suggest to use neutron reflectometry to study the adsorption behavior of short RNA molecules to insoluble monolayers of zwitterionic and cationic lipids.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24079487
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24079487
Provenance
Creator Professor Tommy Nylander
Publisher ISIS Neutron and Muon Source
Publication Year 2014
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2010-08-11T07:31:14Z
Temporal Coverage End 2011-11-01T09:12:55Z