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Molecular responses of calcifying and non-calcifying Antarctic benthic specie...
Southern Ocean organisms are thought to be particularly vulnerable to ocean acidification, as they inhabit cold waters where calcite-aragonite saturation states are naturally... -
Surface adsorption of lipopeptides: interfacial layer structure
Lipopeptide surfactants are highly effective at reducing interfacial tension. However, there is a general lack of understanding of the relationship between their molecular... -
Further SANS contrast measurements on important protein/DNA interactions from...
This proposal is to perform further SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an... -
Investigation on the structural properties of doxorubicin-loaded PEGylated li...
Doxil® is a marketed liposomal formulation containing the anticancer drug doxorubicin. Recently, SAXS measurements have evidenced a crystalline fibrillar structure for the... -
Cubosomes as biosensors: A kinetic study of changes to lattice parameter and ...
Lipid bicontinuous cubic phases are self-assembled three dimensional lattices, consisting of a single periodic bilayer interwoven by two independent water channels. They can be... -
Measurement of the hydration of B-DNA
Water is intimately entwined structurally with DNA. Depending on its hydration state, DNA can form several forms: A, B, C, D and Z. In addition water bound in the grooves of the... -
Structural studies of Staufen1 in complex with Upf1, a crucial assembly in ge...
Gene expression is regulated during both the synthesis and the decay of mRNAs. Various pathways of cytoplasmic mRNA decay exist. These include ARE-mediated decay, miRNA-Mediated... -
Reconstitution of human dihydroorotate dehydrogenase into lipid-detergent mic...
Human dihydroorotate dehydrogenase (DHODH) is an integral membrane protein found in mitochondria involved in the biosynthesis of pyrimidines. DHODH oxidizes dihydroorotate with... -
CLIC1 Protein Interactions with Model Cell Monlayer Membranes
This dataset has no description
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Examining the Structural Changes of a Central Nervous System Neurotransmitter...
GluR0 is a glutamate sensitive potassium ion channel from the cyanobacterium Synechocystis which has been identified via primary structural sequencing to be similar to... -
Short peptide self-assembly and pesticide solubilisation in binary surfactant...
This dataset has no description
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Pinning down pinholin: a structural mechanism to explain how peptide adsorpti...
We will use specular and off-specular neutron reflectivity to provide a structural mechanism for the way in which the amphipathic peptide pinholin controls bacterial cell lysis... -
Structural study on the 3D arrangement of (hexa-acyl) lipid A in lipid membrane
This study will focus on the structural investigations of the bilayers formed on silicon substrates in which the outer leaf consists of DOPE/LPS mixtures. We aim is to achieve... -
Solution structures of the immunologically important proteins IgA, C3 and IgG
Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its... -
Structure-function studies of Replication Protein A and its complexes with DNA.
Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds... -
Effects of curvature and temperature on structure of lipid-polymer nanodiscs
Nanostructured lipid aggregates offer enormous potential as tools for membrane structural biology and biophysics. Styrene-Maleic Acid Lipid Particles have a number of attractive... -
Magnetic contrast reflectometry to resolve transmembrane potential effects on...
The division of bacteria is controlled by the binding of proteins to the inner of the two lipid bilayer membranes that separates the inside of the cell from the outside world.... -
Peptide resistance in asymmetric MRSA-mimetic vesicles
We have been investigating the influcence of the cationic staphylococcal lipid lysyl-phosphatidylglycerol (L-PG) on bacterial resistance to antimicrobial peptides (AMPs). Using... -
Dynamics of amyloid protein fibril elongation using isotope-labelled SANS
This proposal combines small-angle neutron scattering with novel labelling strategies to investigate amyloid protein fibrils. Variations in packing and in the dynamics of... -
Interaction between RNA and lipid monolayers
The objective of the suggested study is to reveal the structure formed when short ssRNA molecules (similar to miRNA) interact with lipid monolayers at the air-water interface....
