46 datasets found

Perfluoroalkyl substances (PFASs) are stable compounds and commercially desirable. They are widely used, for example, as surfactants in textile and paper products and in aqueous...

We have previously studied the adsorption of anti-beta-hCG at the hydrophilic silicon oxide/water interface and the subsequent binding by antigen hCG. We propose to extend this...

The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaire’s disease. It is important as; a barrier to antibiotics & the site of...

In this proposal, we request beamtime to study the very unexpected adsorption behaviour of the surfactant bis(2-ethylhexyl) sulfosuccinate potassium and ammonium salt (K(AOT)...

Benzotriazole (BTAH) is a very effective corrosion inhibitor for copper and its alloys in both water and in oils. BTAH is introduced as a corrosion inhibitor in oil based...

We propose to investigate the interfacial adsorption of a series of water-soluble single chain PC surfactants using neutron reflection, focusing on assessing the effects of...

We have designed a series of cationic peptides with different helix repeats that can kill bacteria but remain benign to mammalian host cells. The selectivity to cell types is...

The objective of the suggested study is to reveal the structure formed when short ssRNA molecules (similar to miRNA) interact with lipid monolayers at the air-water interface....

The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the...

Objectives of this proposal aim to shed light on how adsorption processes such as protein A chromatography, used to purify biologics, affect protein propensity for aggregation....

Tissue Factor (TF) is a membrane protein located on the cell surfaces of extravascular cells. TF activity is fundamental for normal homeostasis- the physiological process which...

We have recently been able to form a thin graphene oxide (GO) film with uniform thickness around 30±2Å from aqueous GO suspensions by spin coating (onto small wafers for...

The bacterial cell envelope is one of the best targets for antimicrobial development. It is this envelope that harbours the instruments of microbial warfare, preventing its...

In recent years we have had considerable success with the surface modification of amorphous and crystalline thermal plastic polymers using multi-end functional additives. In...

The gram-negative bacterial membrane is of extreme medical importance. The two main lipid components of the outer membrane are lipopolysaccharides (LPS's) and DOPE. We will...

The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaire?s disease. It is important as; a barrier to antibiotics & the site of...

The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the...

The bacterial cell envelope is one of the best targets in antimicrobial development. This proposal focuses on understanding how lipids move between the membranes of the...

The current project aims at elucidating how bile salts (BS) structure influences their interfacial behaviour and their impact on fat digestion. Neutron reflectivity (NR) is the...

Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a...