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The Interaction of Puroindoline-b with Model Phospholipid Bilayers
Puroindolines are basic cystiene rich proteins which possess unique Trp rich domains which are fully conserved in the predominant isoform Pin-a and partially in Pin-b. This... -
Membrane interactions of virus-like silica nanoparticles as antimicrobial pep...
As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are currently attracting significant interest. However,... -
Structural study on the 3D arrangement of (hexa-acyl) lipid A in lipid membrane
This study will focus on the structural investigations of the bilayers formed on silicon substrates in which the outer leaf consists of DOPE/LPS mixtures. We aim is to achieve... -
Using Magnetic Contrasts to Establish the Mechanism and Kinetics of Lipid Fli...
In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied... -
Neutron reflectivity studies of the interaction of amphotericin with model ce...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
Interaction between RNA and lipid monolayers
The objective of the suggested study is to reveal the structure formed when short ssRNA molecules (similar to miRNA) interact with lipid monolayers at the air-water interface.... -
Exploring the exact morphology and self assembly characteristics of novel pol...
We would like to use SANS to explore the mechanism for preparation and properties of cylindrical micelles. We hope to obtain key information relating to the growth mechanism... -
Phase Separation in Organic Photovoltaic Cells
Organic photovoltaic (OPV) cells have the potential to be the basis of a renewable energy source that is inexpensive and portable. Current state-of-the-art solution-processed... -
Floating Bilayer Mimics of the Gram Negative Bacterial Outer Membrane
The gram-negative bacterial membrane is of extreme medical importance. The two main lipid components of the outer membrane are lipopolysaccharides (LPS's) and DOPE. We will... -
The Kinetics of Ethanol Adsorption into Cholesterol Rich Bilayers
In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed... -
Calcium mediated interaction between siRNA and phospholipid bilayers: the eff...
The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the... -
Head Group charging and anaesthetic Interaction with Model Bilayers
The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers... -
Selective recruitment of cholesterol to lipid rafts by multivalent protein bi...
Lipid raft microdomains offer a means to enhance the local concentration of membrane components as well as serve as a platform for raft associated endocytosis. Driven by... -
Neutron Reflectivity study of lipopolysaccharide complexes with lateral domai...
We propose to investigate the role of lateral phase separation on LPS insertion into model membranes and the effects of target membrane structure and composition. A comparison... -
Determining the Induced Magnetism in Graphene by High-Angle Polarised Neutron...
The aim of this proposal is to measure the induced magnetic moment in graphene arising from the proximity effect in the vicinity of a ferromagnetic substrate using high-angle... -
Composition depth profiling of novel spray-coated plastic solar cell materials
We propose to study a range of new lower energy gap organic photovoltaic (OPV) materials deposited by spray coating using neutron reflectivity. The new materials to be studied... -
Chloride Intracellular Channel insertion into Tethered Bilayer Membranes
Part One of the proposal is concerned with the fundamental structure of the TBM and aims to determine: (i) the impact of spacer molecule length on the dimensions of the bilayer... -
Structural characterisation of vaccine-adjuvant interactions using neutron re...
This dataset has no description
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Magnetic contrast NR to resolve MscL opening under PXG challenge: influence o...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock, but, as with all ion channels, they have the potential to act as an Achilles heel,... -
Bilayer modification and charge screening by simple ions
Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported DPPC bilayer films. At low concentrations...
