33 datasets found

Puroindolines are basic cystiene rich proteins which possess unique Trp rich domains which are fully conserved in the predominant isoform Pin-a and partially in Pin-b. This...

A number of studies have determined that non-ionic surfactants are capable of altering diffusionrates and transportation of both water and active ingredients thorough the waxy...

An understanding of surfactant aggregation on clay surfaces is important for detergency processes such as cleaning and pollutant removal. Studies have shown that the adsorbed...

Neurotransmitter transporters recognize biogenic amines dopamine, serotonin, noradrenalin and γ-amino butyric acid (GABA). They all belong to the family of...

We will use specular and off-specular neutron reflectivity to provide a structural mechanism for the way in which the amphipathic peptide pinholin controls bacterial cell lysis...

In the context of a project in collaboration with ISIS that focuses on structural studies under mechanical confinement, with a specific focus on biological lubricants, the...

Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further...

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿...

The objective of the suggested study is to reveal the structure formed when short ssRNA molecules (similar to miRNA) interact with lipid monolayers at the air-water interface....

The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the...

The gram-negative bacterial membrane is of extreme medical importance. The two main lipid components of the outer membrane are lipopolysaccharides (LPS's) and DOPE. We will...

In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed...

The division of bacteria is controlled by the binding of proteins to the inner of the two lipid bilayer membranes that separates the inside of the cell from the outside world....

Physical developer (PD) is a latent fingerprint development technique that is highly effective on paper and related surfaces, notably banknotes. The process exploits a redox...

Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes. The conjugation of polymers to these peptides renders the...

Chloride Intracellular Channels (CLICs) are a family of 6 proteins that have in common a C-terminal CLIC module and chloride-selective ion channel activity. CLIC1 is a 241...

We propose to investigate the role of lateral phase separation on LPS insertion into model membranes and the effects of target membrane structure and composition. A comparison...

The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers...

The objective of the present study is to investigate the interaction between PAMAM dendrimers and solid supported model biomembranes of high fluidity. These membranes consist of...

Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported DPPC bilayer films. At low concentrations...