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Detailed Structure of Phospholipid Bilayers from Multiple Contrast Neutron Re...
In recent monolayer measurements, we have developed models for obtaining detailed structural information of phospholipid structures. The models employ a 'quasimolecular'... -
Effect of End Group on RAFT-Polymers for Lipid Nanodisc Stabilisation
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using... -
Adsorption of Sodium Bis-(2-ethylhexyl)phosphate on a-Alumina
In this proposal we investigate the adsorption of a key additive and functional group used in lubrication and wear applications using neutron reflection on a metal oxide... -
Effects of curvature and temperature on structure of lipid-polymer nanodiscs
Nanostructured lipid aggregates offer enormous potential as tools for membrane structural biology and biophysics. Styrene-Maleic Acid Lipid Particles have a number of attractive... -
SANS studies of mixed phsopholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Interaction between RNA and lipid monolayers
The objective of the suggested study is to reveal the structure formed when short ssRNA molecules (similar to miRNA) interact with lipid monolayers at the air-water interface.... -
Oxidation of bilayer of DPPC on a mineral interface by aqueous OH radical ki...
Oxidation of atmospheric aerosol can produce cloud condensation nuclei capable of changing the reflectivity and lifetime of clouds. The oxidation of organic film on atmospheric... -
Purothionins Perturb Bacterial Membrane Function via Ion Channel Formation
Purothionins are a family of cationic cystiene rich plant defence proteins which have been shown to have a wide spectrum of activity due their ability to permeate cellular... -
The Kinetics of Ethanol Adsorption into Cholesterol Rich Bilayers
In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed... -
Using SANS to understand the structure and behaviour of surfactants in chocolate
Molten chocolate is a semi-solid suspension of (mostly) sugar, but also cocoa and milk solids in oil. In order to allow the sugar grains to flow past each other, either when the... -
Head Group charging and anaesthetic Interaction with Model Bilayers
The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers... -
Interactions of Surfactant Mixtures with Phospholipid Vesicles: the Influence...
Surfactants have been widely used in cosmetics, detergents and pharmaceutical industries. These applications are always accompanied by surfactant-induced skin irritation which... -
DPPC bilayer oxidation by aqueous singlet oxygen
Oxidation of membrane lipids by Reactive Oxygen Species, ROS, in cells may impact ageing, cell apoptosis and cancer. We propose to use our skills obtained studying the oxidation... -
Neutron reflection from nanoparticles interacting with insoluble monolayers
Cell-nanoparticle interactions are complex, involving several specific and non-specific intermolecular forces between a wide range of particulate and molecular species . There... -
Surface adsorption of lipopeptides: interfacial layer structure
Lipopeptide surfactants are highly effective at reducing interfacial tension. However, there is a general lack of understanding of the relationship between their molecular... -
Selective recruitment of cholesterol to lipid rafts by multivalent protein bi...
Lipid raft microdomains offer a means to enhance the local concentration of membrane components as well as serve as a platform for raft associated endocytosis. Driven by... -
Penetration and reaction of hydroxyl radical into organic films at the air-wa...
The Earth¿s climate is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects droplet size and optical properties, important climatic effects.... -
Orientation of an Antimicrobial Peptide in Eukaryotic and Prokaryotic Membranes.
Antimicrobial peptides are small, usually alpha-helical peptides that kill cells by disrupting the cell membrane. Recently, we have been studying a simple 'designed'... -
Realistic bacterial membrane mimetics to understand antimicrobial activity & ...
We will use neutron reflectivity measurements of lipopolysaccharide (LPS) layers at the air-water interface to help develop a realistic mimetic for the periphery of bacteria... -
Conformation of di-stearoyl-polyethylene glycol surfactants as enhancers of b...
This proposal relates to the structural studies of Di-stearoyl and di-palmitoyl Polyethylene glycol derivates as a function of the PEG head group at the air-water and the...
