Lipopolysaccharide Functions as Bacterial Receptors to Antimicrobial Peptides

DOI

Neutron reflection (NR) is well established for studying molecular films such as lipid monolayers. Its high depth resolution combined with deuterium labelling can determine the amount and location of binding of antimicrobial peptides (AMPs). By unravelling how AMPs interact with model lipopolysaccharide (LPS) membranes NR can help us to develop strain-specific AMPs to target at Gram-negative bacteria whilst tuning their biocompatibility to mammalian cell hosts. we request 3 days on INTER or 4 days of Surf to complete this work. Inter is preferred due to weak but measurable signals from h-lipid-h-peptide in NRW.

Identifier
DOI https://doi.org/10.5286/ISIS.E.98001371
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/98001371
Provenance
Creator Dr Mingrui Liao; Mr KE FA; Dr Zongyi Li; Mr Haoning Gong; Professor Jian Lu; Dr Luke Clifton; Dr Mario Campana; Miss Daniela Ciumac; Mr Peter Hollowell
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Natural Sciences; Physics
Temporal Coverage Begin 2018-09-21T08:00:00Z
Temporal Coverage End 2018-10-04T19:47:56Z