-
Protein nanosheets assembled structures at the air-water interfaces for cell ...
Cell adhesion and proliferation at the surface of liquids such as oil droplets is a surprising phenomenon as it is typically accepted in the field of bioengineering that cells... -
Neutron reflection study into the adsorption and penetration of non-ionic alk...
We propose to explore how to use NR to study the structural features of the reconstituted plant wax films, capturing the main structural characteristics. In addition, we propose... -
Adsorption of an Anionic Surfactant on Anionic Surfaces in the Presence of Po...
In this proposal, we request beamtime to study the very unexpected adsorption behaviour of the surfactant bis(2-ethylhexyl) sulfosuccinate potassium and ammonium salt (K(AOT)... -
Charged nanogels interactions with model lipid membranes
In recent years nanogels show great potential as drug delivery systems. Especially dermal drug administration which is non-invasive, helps to avoid the first-pass effect with... -
Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic lipid bil...
Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug... -
How does oxidative damage change peptide membrane insertion?
The insertion of peptides and proteins into cell membranes is crucial for the functioning of cells, and also for the functioning of a variety of antibacterial reagents. Cells... -
pH-control of swelling and charge neutralization of thin hydrogel films
Hydrogels are widely used in biomaterials science, much due to excellent protein resistance, and physicochemical properties similar to biological tissue. Charge neutrality is... -
Structural studies of protein at the oil-water interface
We would like to measure the adsorption isotherm for protein, milk B-casein using neutron reflectometery at the oil-water interface. These measurements will be carried out for... -
Probing the structure/function relationship of NhaA protein incorporated into...
We propose to perform combined measurements of neutron reflectometry (NR) and impedance spectroscopy (IS) to investigate the structure/function relationship of tethered bilayer... -
Effect of Cholesterol on NHE1 intracellular domain adsorption on lipid bilayers
The Na+/H+ exchanger isoform 1 (NHE1) is a transmembrane protein with the primary function of regulating the pH in the cytosol by exchanging one proton with one Na+ ion. The... -
Adsorption of NHE1 intracellular domain on lipid bilayers
Recently the intracellular domain (ICD ) of the Na+/H+ exchanger isoform 1 (NHE1), is a transmembrane protein, has been identified as an intrinsically disordered protein.... -
Charged nanogels and their ability to penetrate model lipid membranes
Drug delivery through the skin is an important route for administration of therapeutic agents. However, the outermost layer of the skin, the stratum corneum provides a... -
Luke Clifton Sample commissioning
This dataset has no description
-
Neutron Reflectivity Study of Protein Adsorption onto Cell Membrane-inspired ...
We grafted 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer brush from the silicon wafer surface through Cu (0) mediated controlled radical polymerization (CuCRP) to mimic... -
Lipopolysaccharide Functions as Bacterial Receptors to Antimicrobial Peptides
Neutron reflection (NR) is well established for studying molecular films such as lipid monolayers. Its high depth resolution combined with deuterium labelling can determine the... -
Organization of mitochondrial membranes upon oxidative stress: Impact on apop...
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a... -
Elucidating the Membrane Interaction Mechanism of Chloride Intracellular Chan...
Chloride Intracellular Channels (CLICs) are a family of 6 proteins that have in common a C-terminal CLIC module and chloride-selective ion channel activity. CLIC1 is a 241... -
Multilayering of Isostearic Methyl Ester Sulphonate at the Air-Aqueous Interf...
Surfactants usually form a single layer of molecules at the surface of water. We have shown that under certain conditions more than one layer may form. in which case the system... -
Interactions between Designed Antimicrobial Lipopeptides and Inner Membrane L...
Neutron reflection will be used to reveal the structural changes from different inner membrane leaflet models upon interacting with a group of antimicrobial lipopeptides with... -
The Impact of Multivalent Counterions on the Surface Adsorption of the Anioni...
Surface multilayer formation provides great potential for the tuning and optimising surface wetting properties and applications such as lubrication, drug delivery. Normally...
