88 datasets found

This work aims to exploit the unique capability of neutron reflection to examine how 2 antimicrobial lipopeptides that tend to adopt different secondary structures bind to model...

The interfacial behaviour of thermoresponsive N-propylacrylamide (NPAM) based nanogels differs from solid nanoparticles because of the soft structural character. These nanogels...

Cell adhesion and proliferation at the surface of liquids such as oil droplets is a surprising phenomenon as it is typically accepted in the field of bioengineering that cells...

We propose to study off-specular polarised neutron reflectivity from an array of CoFeB nanostructures. Many groups use Permalloy to form these types of nanostructures, however,...

X-ray, electron and neutron scattering techniques have been used for the structural characterization of surfaces and embedded morphologies. Several theories have been developed...

In this proposal we investigate the adsorption of a key additive and functional group used in lubrication and wear applications using neutron reflection on a metal oxide...

In recent years nanogels show great potential as drug delivery systems. Especially dermal drug administration which is non-invasive, helps to avoid the first-pass effect with...

Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug...

The insertion of peptides and proteins into cell membranes is crucial for the functioning of cells, and also for the functioning of a variety of antibacterial reagents. Cells...

Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is...

We propose to study a range of new selenium containing lower energy gap organic photovoltaic materials deposited by spray coating using neutron reflectivity. The new materials...

Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further...

Hydrogels are widely used in biomaterials science, much due to excellent protein resistance, and physicochemical properties similar to biological tissue. Charge neutrality is...

Tissue Factor (TF) is a membrane protein located on the cell surfaces of extravascular cells. TF activity is fundamental for normal homeostasis- the physiological process which...

The aim is to use Neutron Reflectivity (NR) to gain essential information on the adsorption properties of fluorocarbon (FC)/ hydrocarbon (HC) mixtures in commercial...

Lipid membranes provide a sensitive platform for a variety of biological functions, and membrane lipid distributions are carefully regulated. In this project we plan to study...

We propose to perform combined measurements of neutron reflectometry (NR) and impedance spectroscopy (IS) to investigate the structure/function relationship of tethered bilayer...

The Na+/H+ exchanger isoform 1 (NHE1) is a transmembrane protein with the primary function of regulating the pH in the cytosol by exchanging one proton with one Na+ ion. The...

We have recently performed a `proof-of-principle' Low Energy Muon Spin Rotation experiment on an organic spin valve. In an extension to our muon measurements and an attempt to...

In this part of the proposed work, we wish to explore how antibiotics and antimicrobial peptides interact with model lipid bilayers in the form of a supported lipid bilayer,...