Detailed Structure of Phospholipid Bilayers from Multiple Contrast Neutron Reflection Data

DOI

In recent monolayer measurements, we have developed models for obtaining detailed structural information of phospholipid structures. The models employ a 'quasimolecular' approach, where the reflectivity data is analyzed using realistic molecular models of the lipids. The advantage of these models is that they can be easily applied simultaneously across multiple contrasts, allowing highly detailed structural information to be obtained from reflectivity data.We now wish to repeat these studies with the more complex, physiological case of bilayers rather than monolayers. The ISIS model membrane system - the Free Supported Bilayer (FSB) - is now reliable and robust enough that a detailed, simultaneous analysis of multiple part-deuterated samples can be contemplated. These measurements will allow us to develop detailed models for better analysing bilayer data from ISIS reflectimeters.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24078427
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24078427
Provenance
Creator Dr Rob Barker; Professor Jayne Lawrence; Dr Dave Barlow; Dr Stephen Roser; Dr Arwel Hughes
Publisher ISIS Neutron and Muon Source
Publication Year 2012
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2009-11-21T09:48:08Z
Temporal Coverage End 2009-11-24T07:58:46Z