20 datasets found

This proposal addresses bilayer swelling experiements on floating supported bilayers (FSBs) in the presence of biological buffers. Previous work on multilamellar vesicles has...

Off-specular neutron reflection is potentially a powerful technique for studying the lateral organisation of phospholipid bilayers. However, this has not yet been demonstrated....

Antibiotic peptides are generally small, simple, usually alpha-helical peptides, which nevertheless show quite complex biological behaviour. We have been studying the gating...

In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied...

In recent years, it has become understood that rather than being homogenous mixtures, biomembranes show a complex phase behaviour, with regions of uniform phases, and others...

We have been developing hydroxypropylmethyl cellulose (HPMC) microspheres for delivering poorly water-soluble drugs. The in vitro dissolution data showed that the presence of...

Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we...

Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported DPPC bilayer films. At low concentrations...

Natural antimicrobials are of great interest, since they are antibiotics that act on the biological membrane, and it is believed that this makes it far more difficult for...

'Floating LSupported Bilayers' (FSB's) have become the 'standard' systems used for studying membrane systems using reflectivity at ISIS and other facilities. They are reliable,...

The objective of the present study is to investigate the interaction between PAMAM dendrimers and solid supported model biomembranes of high fluidity. These membranes consist of...

The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers...

Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering...

There is currly great interest in the use of neutron reflection to study model bilayers. We have produced a model membrane system that is strongly associated with the substrate,...

Cell-nanoparticle interactions are complex, involving several specific and non-specific intermolecular forces between a wide range of particulate and molecular species . There...

The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers...

In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed...

Nearly 40% of new chemical entries are poorly water-soluble. Drug encapsulation into water-soluble polymers is an active research area owing to the ability of improving drug...

In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied...

In recent monolayer measurements, we have developed models for obtaining detailed structural information of phospholipid structures. The models employ a 'quasimolecular'...