-
The interaction of cytochrome c with floating bilayers containing negatively ...
As research on apoptosis has gained momentum, the importance of membrane lipids in this crucial cellular process is becoming clear.Previously, we have determined using NR and... -
Structure of oil-in-water microemulsions containing eutectic mixtures of ment...
Although microemulsions have been widely investigated as potential drug delivery vehicles, relatively little work has been performed establishing the detailed molecular... -
Detailed Structure of Phospholipid Bilayers from Multiple Contrast Neutron Re...
In recent monolayer measurements, we have developed models for obtaining detailed structural information of phospholipid structures. The models employ a 'quasimolecular'... -
Surface structure of monolayers formed by novel di- and tri-chain cationic li...
The aim of the present study is to the determine, using specular neutron reflection (SNR), the structure of layers formed by novel tri-chain cationic lipids in combination with... -
Neutron reflectivity studies of the interaction of amphotericin with phosphol...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
SANS studies of mixed phsopholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Neutron reflectivity studies of the interaction of amphotericin with model ce...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
Magnetic study of the new skyrmion-carrying material CoZnMn
Nanoscale magnetic skyrmions are swirl-like magnetisation entities that satisfy topological quantisation conditions. They can therefore not be easily unwound into another... -
Probing the internal structure of ethyl butyrate containing microemulsions us...
The proposal aims to establish the location of the oil, ethyl butyrate in dodecyldimethylamine-N-oxide (DDAO) microemulsions. Molecular dynamic simulations have proposed that a... -
The effect of anionic lipid unsaturation on the interaction with cytochrome c
While peripheral membrane protein-lipid interactions were originally considered to be solely electrostatic in nature, it is now accepted that they encompass more complicated,... -
SANS studies of Amphotec (aggregates of amphotericin-cholesteryl sulfate)
The anti-fungal agent amphotericin B (AmB) can be administered to patients in aqueous solution complexed with cholesteryl sulfate (CS), and this formulation helps to minimise... -
Kinetics of amphotericin B interaction with model human and fungal cell membr...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of... -
Probing the internal structure of gene delivery vehicles using contrast varia...
Gene delivery vehicles, known as LPD complexes, prepared from mixing cationic lipid vesicles (L) with cationic peptide (P) and DNA (D) have proven to be very effective at... -
SANS studies of mixed phospholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
The calcuim mediation interaction of DNA with monolayers of DSPC and DOPE
The main objective of the present work is to complete some work aimed at gaining an understanding of the interaction of phospholipid membranes containing the neutral helper... -
Planar bilayer formation on novel cationic surface suitable for membrane prot...
Membrane receptor proteins (MRPs) which are thought to represent the majority of drug targets are challenging to study as their structure and function is dependent on being... -
Molecular architecture of monolayers formed by novel sterol-modified phosphol...
A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative... -
Effect of surfactant head group on micelle structure of drug containing micelles
The aim of the current project is to probe (at the nanometer length scale) the relationship between the solution structures of a surfactant molecule, the aggregate(s) it forms... -
SANS studies of phospholipid:sterol vesicles and the membrane interactions of...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Conformational change of glycerol faciliitator protein on substrate binding
A large family of membrane channel proteins selective for transport of water (aquaporins) or water plus glycerol (aquaglyceroporins) has been found in diverse life forms. E....
