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The interaction of cytochrome c with floating bilayers containing negatively ...
As research on apoptosis has gained momentum, the importance of membrane lipids in this crucial cellular process is becoming clear.Previously, we have determined using NR and... -
Interactions of artificial membrane binding proteins with model membranes
This dataset has no description
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Detailed Structure of Phospholipid Bilayers from Multiple Contrast Neutron Re...
In recent monolayer measurements, we have developed models for obtaining detailed structural information of phospholipid structures. The models employ a 'quasimolecular'... -
Probing membrane localisation of molecular rotors
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Pinning down pinholin: a structural mechanism to explain how peptide adsorpti...
We will use specular and off-specular neutron reflectivity to provide a structural mechanism for the way in which the amphipathic peptide pinholin controls bacterial cell lysis... -
Using Magnetic Contrasts to Establish the Mechanism and Kinetics of Lipid Fli...
In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied... -
Membrane-stacking Properties of Mutant Myelin Proteins
Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further... -
Neutron reflectivity studies of the interaction of amphotericin with model ce...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
The Kinetics of Ethanol Adsorption into Cholesterol Rich Bilayers
In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed... -
Head Group charging and anaesthetic Interaction with Model Bilayers
The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers... -
Elucidating the Membrane Interaction Mechanism of Chloride Intracellular Chan...
Chloride Intracellular Channels (CLICs) are a family of 6 proteins that have in common a C-terminal CLIC module and chloride-selective ion channel activity. CLIC1 is a 241... -
Antimicrobial Peptide Binding & Rearrangement in Model Membranes ¿ Building a...
Antimicrobial peptides (AMPs) are attractive drug candidates because of their selectivity and speed of action against bacteria. We have developed a novel approach to delivering... -
Planar bilayer formation on novel cationic surface suitable for membrane prot...
Membrane receptor proteins (MRPs) which are thought to represent the majority of drug targets are challenging to study as their structure and function is dependent on being... -
Molecular architecture of monolayers formed by novel sterol-modified phosphol...
A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative... -
Role of apolipoprotein E variant on HDL interactions at model cell membranes
Atherosclerosis is the leading cause of death in western society, its consequences such as strokes and heart attacks arise from the build-up of plaques of fat which accumulate... -
Investigation of the translocation potential of therapeutic macromolecules in...
Exosomes are released by cells are responsible for cell-cell communication of macromolecules and the development of disease such as cancer. These nanoparticles are loaded with... -
Effect of calcium ions and ionic strength on model bilayer structure
Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we... -
Conformational analysis of subtilin / lipid II binary antibiotic/target membr...
We propose to use neutron reflection to characterise the position and shape of subtilin/lipid II pore complexes as well as to characterise the kinetics of subtilin-lipid II and... -
Interfacial conformation of antibody and antigen binding capacity
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element... -
The Mechanism and Kinetics of Lipid Flip-Flop in Floating Phosphatidylcholine...
In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied...
