43 datasets found

Puroindolines are basic, cysteine rich proteins of ~13KDa, which have attracted significant interest due to their role in determining the endosperm texture of Wheat and seed...

This proposal addresses bilayer swelling experiements on floating supported bilayers (FSBs) in the presence of biological buffers. Previous work on multilamellar vesicles has...

Off-specular neutron reflection is potentially a powerful technique for studying the lateral organisation of phospholipid bilayers. However, this has not yet been demonstrated....

Antibiotic peptides are generally small, simple, usually alpha-helical peptides, which nevertheless show quite complex biological behaviour. We have been studying the gating...

In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied...

In recent years, it has become understood that rather than being homogenous mixtures, biomembranes show a complex phase behaviour, with regions of uniform phases, and others...

Lung surfactant protein B, SP-B, is found at the air-water interface of the lung. A deficiency in SP-B at birth is known to be fatal. We have recently successfully studied the...

Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported bilayer films. In this proposal we...

The structure of colloidal crystals (dispersions of particles that spontaneously order in a regular array) is known to be influenced by solid boundaries. However there are few...

The Earth¿s climate is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects cloud droplet size and optical properties, important climatic...

Several interesting results have emerged in studies of Aerosol-OT at the sapphire/solution interface that relate to effects of counter-ions, insensitivity to pH as well as the...

A large family of membrane channel proteins selective for transport of water (aquaporins) or water plus glycerol (aquaglyceroporins) has been found in diverse life forms. E....

Lung surfactant protein B, SP-B, interacts with lipids at the air-water interface of the lung where its presence is vital for correct respiratory function. SP-B and its...

Lithium ternary nitrides are emerging as promising anode materials in lithium ion batteries. In this application we propose a 1 day experiment on POLARIS to determine the...

Polystyrene latex represents an excellent model system for studies of the physical properties of colloidal particles. The materials can be prepared with controlled size, and...

Calcium ions have been shown in a preliminary experiment to have a dramatic effect on the thickness and structure of free supported DPPC bilayer films. At low concentrations...

Highly ordered dispersions of charged polymer particles that are tens or hundreds of nanometres diameter can be prepared. These are useful model systems for self-assembly and...

Natural antimicrobials are of great interest, since they are antibiotics that act on the biological membrane, and it is believed that this makes it far more difficult for...

Membrane receptor proteins (MRPs) which are thought to represent the majority of drug targets are challenging to study as their structure and function is dependent on being...

Exposure to ozone gas can cause inflammation of the airways and breathing difficulties. The initial reaction of ozone is thought to be predominantly with lipids present in the...