The research topic is encapsulation of a hydrophobic drug, flurbiprofen, using novel amphiphilic graft copolymers (AGCs). The AGCs of interest are shown in Figure 1: Preliminary Small-angle neutron scattering (SANS) has been used to characterize the conformation of the P123 and P103 Pluronic graft copolymers in selective solvents such as ethanol and water in the presence of flurbiprofen. The results indicate that, when the drug is added into the solution of grafted copolymers, an increase in the inner (Rin/Å) and outer radius (Rout/Å) is observed. Also results by diffusion NMR show a distinct decrease in the attenuation of drug (decrease in diffusion coefficient), which indicate that the drug is interacting with micelles. The proposal is being of significance in designing potential drug carriers that are not concentration sensitive.