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Engineering nanoparticles for protein therapeutics - quantifying membrane acc...
The self-assembly properties of lipid systems can be exploited to form lipid membranes with complex morphologies. These include membranes with a lattice-type internal structure... -
Investigation of Folded Globular Maltose Binding Protein Based Hydrogels
We have developed a new model to describe the structural architecture of hydrogels composed of cross-linked maltose binding proteins (MBP), supported by multiple techniques... -
Interaction of the intrinsically-disordered linker histone C-terminal tail wi...
In cells, the genome needs to be tightly packaged in the nucleus as "chromatin" while still allowing access to the cellular machinery responsible for gene expression. The first... -
Self-assembly of lipid and triblock copolymer-based amphiphiles for drug deli...
Soft self-assembled structures have been extensively used as drug nanocarriers. Their building blocks, naturally occurring and synthetic amphiphiles (lipids or block... -
Exchange kinetics of telechelic Cn-PEO-Cn micelles: effect of conformation an...
The microscopic dynamics of associative polymers that self-assemble into micellar structures play a key role for their macroscopical properties, with important implications for... -
Effect of emulsifier and added preservative on the structure and stability of...
Investigations will be performed to determine the effect of composition on the internal structure of semi-solid oil-in-water emulsions designed to model the GlaxoSmithKline... -
Perfluorocarbon-loaded polymeric nanoparticles with multiple perfluorocarbon ...
Ultrasound is a very attractive and patient-friendly imaging technique, as it is easy to use, fast and non-invasive. Nevertheless, its use is severely limited by the low... -
How aggregate lifetimes affect the kinetics of surfactant surface multilayer ...
The spontaneous formation of multilayer structures at interfaces from surfactant self-assembly is an important structural signature associated with a wide range of technological... -
Investigating the effect of nanoparticles on PBI self assembly
The generation of hydrogen from water using light could be a method of providing a clean fuel, which is clearly important for our growing energy needs. We are using perylene... -
Concentrated emulsions as proxy CO2 thickeners
The proposal aims to explore the oil-in-water (brine) high internal phase emulsion systems (HIPEs) formed by nonylphenol ethoxylate surfactants using contrast variation SANS... -
Polymer-Lipid Nanodisc Self-assembly Processes Using Stop Flow
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs... -
Bulk interactions of surfactant molecules in aqueous particle suspensions
Surfactants represent an important class of compounds owing to their ability to readily locate at interfaces, be it airliquid, liquidliquid or solidliquid. As such,... -
Cationic surfactant self-assembly in choline chloride:malonic acid deep eutec...
Deep Eutectic Solvents (DES) are mixtures of organic salts and hydrogen bond donors, that form strongly hydrogen-bonded room temperature ionic liquids (ILs). DES share many... -
Nanostructuring of Polyphilic Liquid Crystals
The organisation of molecules in liquid crystal phases relies on many factors, often related to space-filling considerations driven by the volume of different molecular... -
Pickering emulsions stabilized with oxidised cellulose nanofibrils and starch
Our group has been working functionalised cellulose nanofibrils which form gels in aqueous formulations. Previously we have used these fibrils to stabilise oil-in-water... -
SANS from photoconductive hydrogel mixtures and their gelators.
Hydrogels are formed from a self?assembled network of fibres made up of small molecules (gelators) trap and hold water at just 1% by weight, or less, from the solution they are... -
Micelle Formation in Lanthanide-Based DES
Deep eutectic solvents (DES) share many features with ionic liquids (ie. tunable physicochemical properties) which makes them viable green solvents that are less toxic than... -
SANS studies of Physiogel creams
Aqueous creams are widely used to treat skin conditions like rosacea, dermatitis and psoriasis.They are very complex chemical mixtures, and our knowledge of their molecular... -
Nanoarchitecture of polyprotein hydrogels
The properties of hydrogels are defined not only by their chemical composition, but also the spatial organization of their components. Applications that require a higher level... -
Solventless protein liquids: a novel form of biological matter
Solventless protein liquids (SPLS) represent a novel form of biological matter. Recently we reported on the preparation and properties of a solvent-free liquid protein based on...