Polymer adsorption from fluorinated media in polymer stabilised drug suspensions

DOI

The formation of stable particle dispersions are essential to the success of a wide range of commercial products from inks, paints and foodstuffs to cosmetic and pharmaceutical formulations. Polymers and surfactants are used routinely to stabilize aqueous dispersions, and these systems have been studied widely. However, significantly less is known about the detailed molecular assembly of polymers adosrbed to the surfaces of drug particles suspended in fluorinated media. Our previous work - through industrial time at the ILL - has shown a complex behaviour. Here we wish to examine the adsoprtion of a series of representative polymer excipients (essentially, poly(ethylene oxide) and their derivatives) to dispersions ofsilica particles in the partially fluorinated solvent, 2H,3H-perfluoropentane (HPFP).

Identifier
DOI https://doi.org/10.5286/ISIS.E.24079323
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24079323
Provenance
Creator Dr Alison Paul; Professor Peter Griffiths; Miss Gemma Talbot; Dr Philippe Rogueda
Publisher ISIS Neutron and Muon Source
Publication Year 2014
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2011-10-24T08:22:05Z
Temporal Coverage End 2011-10-25T07:58:41Z