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Self-assembly of protein polymer conjugates: Effect of copolymer structure
Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation or crosslinking resulting in lack of... -
Comparasion of the Formation of Linear/Linear interpolymer complex and Linear...
Polymers with specific functional groups on their main chains or side chains can interact with each other either in solution or in bulk, forming interpolymer complexes, for... -
Structure of the interaction between complement factor H (CFH) and complement...
Complement comprises key proteins in innate immunity that forms a major defence and clearance system in blood. CFH is the major regulator of active C3b formed from C3. C3d is a... -
Polymer adsorption from fluorinated media in polymer stabilised drug suspensions
The formation of stable particle dispersions are essential to the success of a wide range of commercial products from inks, paints and foodstuffs to cosmetic and pharmaceutical... -
Solution structures of the immunologically important proteins IgA, IgG and C3
Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its... -
SANS Investigation on Packing Structure of Proteasome Activator 28
Proteasome plays an important role in the processing of antigenenic proteins for presentation by the MHC class I pathway. PA28 is an activator of the 20S proteasome, a large... -
Membrane perturbation and permeabilization by the lysosomotropic detergent MSDH
Lysosomes are subcellular organelles with acidic interiors (pH 3.5-5), containing enzymes that break down macromolecules and intracellular waste. Controlled release of lysosomal... -
Solution structures of the immunologically important proteins IgA, C3 and IgG
Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its... -
Understanding the properties of nucleobase functionalized nanostructures
We have recently prepared a number of new nucleobase functionalised polymers which undergo interesting and unexpected self-assembly. We hope to use SANS to explore further the...