Micro-Metagenomics: Characterising Virus-Surface Interactions for Microfluidic Diagnosis

DOI

Traditional methods of viral detection are based on the isolation and culture of viral pathogens, but often viruses cannot be cultivated under laboratory conditions, constituting a substantial barrier to viral diagnostics and discovery. Microfluidics is a multidisciplinary field in which low volumes of fluids are used in high-throughput screening. Therefore, when combined with appropriate system and filter designs, microfluidics could make the ideal technology for the filtering, detection and quantification of viruses within a sample. This proposal is an integral part of a one year pump-prime project to analyse the properties of viruses which differ substantially in size, shape & deformability on different microfluidic surfaces. This information from neutron reflectivity and scattering will be used to inform mathematical modelling leading to initial trial microfluidic devices.

Identifier
DOI https://doi.org/10.5286/ISIS.E.87815621
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/87815621
Provenance
Creator Dr Timm Krüger; Dr Richard Orton; Dr Mario Campana; Dr Rob Barker; Miss Alix Blissett; Miss Chloe Marie Skingle; Miss Irantzu Yoldi; Miss Erin Fuller
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Medicine
Temporal Coverage Begin 2018-10-21T08:00:00Z
Temporal Coverage End 2018-10-23T08:02:26Z