Structure of oil-in-water microemulsions containing eutectic mixtures of menthol and drug as oil

DOI

Although microemulsions have been widely investigated as potential drug delivery vehicles, relatively little work has been performed establishing the detailed molecular architecture of the drug-containing microemulsions. The present study uses the novel approach of using a eutectic mixture of menthol and the drug lidocaine as the oil to prepare a pharmaceutically acceptable microemulsion. Small angle neutron scattering measurements in combination with contrast variation will be used to determine the location of the eutectic mixture in the microemulsion as a function of composition and surfactant (either dodecyldimethylammoniopropane-sulfonate, sodium dodecyl sulphate or dodecyl trimethyl ammonium bromide). The proposed study forms an integral part of a large on-going project in our laboratory investigating the potential of surfactant and lipid aggregates as drug delivery vehicle

Identifier
DOI https://doi.org/10.5286/ISIS.E.24079811
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24079811
Provenance
Creator Professor Jayne Lawrence; Dr Dave Barlow; Ms Fabrizia Foglia; Dr Hisham Al-Obaidi
Publisher ISIS Neutron and Muon Source
Publication Year 2013
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2010-05-21T07:51:16Z
Temporal Coverage End 2010-05-24T08:29:35Z