Recent research has demonstrated the potential of nanosized delivery systems for routine use in many diseases, eg cancer, viral diseases and rheumatoid arthritis [1,2], due to an improved patient efficacy and convenience. Despite the clinical advantages of liposomal anticancer drugs such as Doxil® (reduced cardiotoxicity, prolonged drug circulation time and tumour targeting by the EPR effect), the relatively slow release of encapsulated drug at the target site limits optimal therapeutic activity [3]. Therefore, we have developed a strategy for triggering the release of drugs encapsulated in liposomes called "polymer enzyme liposome therapy" (PELT) [4]. PELT utilises a polymer-bound enzyme to trigger the release of drug encapsulated within a liposome [5].Here, we wish to undertake a neutron study to fully characterise the structure of this liposome-polymer-enzyme complex.