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CATIONIC POLYMERS AS POTENTIAL GENE DELIVERY AGENTS: EVALUATION OF CONFORMATI...
Bio-responsive polymers hold great promise as delivery vehicles for drugs, peptides and proteins as their chemistry can be tuned to effect a change in physico-chemical... -
Controlled Assembly of Cationic Polythiophene-Surfactant Complexes
We intend to study the phase behaviour of 2 cationic polythiophenes, P3MAHT and P3ImiHT, in the presence of the perfluorinated surfactant potassium... -
Aggregation behaviour of aqueous hairy rod conjugated polyelectrolyte/surfact...
Small angle neutron scattering (SANS) will be used to characterise the structures of aggregates formed between the anionic conjugated polyelectrolyte... -
Peptide resistance in asymmetric MRSA-mimetic vesicles
We have been investigating the influcence of the cationic staphylococcal lipid lysyl-phosphatidylglycerol (L-PG) on bacterial resistance to antimicrobial peptides (AMPs). Using... -
Temperature-dependent structural behaviour of the collapse transition of high...
We shall use small angle neutron scattering to investigate the structural behaviour of the temperature sensitive highly branched poly(N-isopropyl acrylamide) [PNIPAM]. These... -
Investigating a Dextrin-Phospholipase A2 Conjugate as a Trigger for Polymer E...
Recent research has demonstrated the potential of nanosized delivery systems for routine use in many diseases, eg cancer, viral diseases and rheumatoid arthritis [1,2], due to... -
Metallomicroemulsions - a new class of supramolecularly organised metal ions
Incorporation of d- or f-block metals into ligand systems that renders a metal complex surface active or drives its partitioning into surfactant phases enables the localisation... -
Kinetics of amphotericin B interaction with model human and fungal cell membr...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of... -
Characterising micelles formed from new polymerizable amphiphiles derived fro...
Amphiphiles derived from amino acids are important functional materials. The amino, carboxyl and side chain groups present in the chemical structure of amino acids provide wide... -
Hydrophobicity ¿ The Key to Polymer-Drug Conjugate Conformation
The use of polymer-drug conjugates for the delivery of drugs to specific sites of disease within the body has shown much clinical promise. It has become clear that the... -
Microemulsion Controlled Polymorph Crystallisation
Control of crystallisation is essential for many applications ranging from pharaceuticals to packaging and food preservation, yet remains extremely challenging. Recently we have... -
Structure in Polymer Conetworks
This proposal is part of a new research programme at Reading which is focused on a new types of macromolecular structures namely conetworks and pseudo-conetworks. These are... -
Opening up microemulsion phases in CO2
New types of water-in-CO2 microemulsions using mixed surfactant systems will be investigated by high-pressure SANS (HP-SANS). Exciting new results (see report on RB820030) have... -
SANS studies of mixed phospholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
SANS study of the structure of surfactant stabilised Pt and Ru nanoparticles
Surfactants have been used to bind and disperse Pt and Ru nanoparticles during their synthesis. In this work, we propose to use SANS to determine the thickness and packing... -
Structure of alkylated aza-crown ether inverse micelles
Ion transfer through fluid-fluid interfaces plays decisive roles in many natural and industrial processes. In studies of Cu(II) transport by Permeation Liquid Membrane (PLM)... -
Study of the interaction of various LPSs with Lactoferrin.
Proposal is focused on the study of the interactions of some lypopolysaccharides (LPSs) with Lactoferrin. LPSs compose about 70-80% of the outer membrane of Gram negative... -
AGGREGATION BEHAVIOUR OF A NOVEL P-AOT SURFACTANT
This proposal aims to provide essential surfactant micellisation structural information of significant interest in its own right but also as key information for our on-going... -
Polystrene chain conformations in good solvents and electrospun fibres
This proposal is centered on the preparation of nanoscale fibres prepared by electrospinning and is the focus of the final year PhD programme of Saeed Mohan. These experiments... -
Co-adsorption of eggshell membrane polypeptide-surfactant mixtures at oil-in-...
An eggshell membrane polypeptide is highly surface active and effective at emulsion stabilization. We explore how to use SANS to study the interfacial layers surrounding the...
