An increasing number of potential drug molecules are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a means of increasing the apparent aqueous solubility of a drug and ensuring exploitation as a medicine. However, little is known about the relationship between drug structure and solubilisation in a micelle. This study focusses on the distribution of the hydrophobic drug, ibuprofen, in surfactant monolayers. Specifically we aim to determine the stiochiommetry and the nature of incorporation of ibuprofen into monolayers formed by 5 different surfactants using neutron reflectivity in combination with contrast variation. Significantly the use of deuterated ibuprofen will allow resolution of its stiochiometry and location in the surfactant monlayer much more accurately than previous studies on related systems.