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The origins of Biosurfactant self assembly
Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce... -
Elucidating the effect of BTHC on DMPC monolayers
Plastic bags are used as containers for storage of donated blood. These bags are often made of PVC plasticized with dialkylphthalates (e.g. DEHP), which migrates into the blood... -
Effect of squalene on membrane structure and Amphotericin B resistance in Can...
The yeast Candida glabrata is becoming an increasing cause of infections. We have developed RNA interference tools that allow us to study the virulence and resistance mechanisms... -
Study of the interfacial self-assembly of peptide/polymer membranes by neutro...
The interfacial self-assembly between large (polymer) and small (peptide) molecules of opposite charge results in the formation of highly organized membranes. Furhter... -
Extreme Synergistic mixing in Biosurfactant ionic surfactant mixtures
The biobased economy growing substantially and pressure to reduce reliance on palm and crude oil derived materials, demand that Home and Personal Care industries develops... -
Ibuprofen containing surfactant monolayers: location and stiochiometry of ibu...
An increasing number of potential drug molecules are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a... -
Determination of the absorbed amount and location of a hydrophobic drug in su...
Many drugs are both poorly water-soluble (hydrophobic) and lipophilic in nature and are therefore incorporated into surfactant micelles and monolayers. As the incorporation of... -
Structures of cardiolipin-bound cytochrome c in pathological conditions
Cardiolipin (CL) is a structurally unique dimeric phospholipid localized in the inner mitochondrial membrane, which is known to provide essential structural and functional... -
Mixed Amino-Acid Based Surfactant Monolayers
Amino acid based surfactants have been known for many years but so far few detailed studies have been carried out on their properties. We are using amino acids extracted from... -
Effect of polar solvent on the structure of monolayers of phospholipid
It is the aim of the proposal is to perform neutron reflectivity (NR) studies combined with contrast variation to determine the structure of phospholipid monolayers on a... -
Steroidal drug containing dodecyl sulphate monolayers: effect of counterion
An number of potential drugs, including steroidal drugs are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant... -
Study of mixed biopolymers at the oil-water interface
Proteins are important in many applications ranging from the stabilisation of emulsions (oil-water interface) to foams (air-water interface). Understanding the relationship... -
Lipodepsipeptides and Brown Blotch Disease in Mushrooms (ii) the role of tola...
Tolaasin is a lipodepsipeptide (lipo = hydrophobic side chain, depsipeptide is an amino acid ring closed in a particular way) produced by strains of Pseudomonas tolaasii, and it... -
Investigation of surface conjugation of proteins in lipid membrane using neut...
Bilayer lipid membranes and their interactions with the integral or peripheral proteins serve as one of the key mechanism in various cellular functions like communication, cell... -
Interfacial structures and competitive adsorption of amphiphilic polymers wit...
Foam stability, appearance and functionality is governed by the thin liquid films between foam bubbles. These films are stabilised by surface active molecules (surfactants and... -
Adsorption of surfactants used in fire-fighting foams
The aim is to use Neutron Reflectivity (NR) to gain essential information on adsorption properties of practical fluorotelomer surfactants used in fire-fighting foam formulations... -
Interactions of lipidic cubic nanoparticles with model lipid biomembranes at ...
Lipidic cubic nanoparticles (LCNPs) have been extensively studied as therapeutic agents and delivery systems due to their biocompatibility, ease of drug encapsulation and... -
Neutron Reflection Studies on Adsorption of Lauroyl-L-Carnitine (C12-L-Caniti...
Acyl L-Carnitines are a group of novel surfactants with attractive physical and biological properties associated with their head group charge features. This work proposes to use...