Folated derivatized nanoemulsions for the treatment of cancer

DOI

Nanoemulsions (NE) i.e. nanoparticles containing a fluid lipid or oil dispersed in water and stabilized by a surfactant particles have attracted considerable attention as vehicles for the delivery of poorly-water soluble drugs. We have recently developed a series of novel nanoemulsions containing soybean oil as the disperse phase and stabilised by the non-ionic surfactant, oleyl polyoxethylene (10) ether. Significantly a proportion of the surfactant molecules contain a folic acid receptor targeting group on the terminal hydroxyl to enable cellular targeting of the nanoemulsions. The proposed SANS study will determine the effect of the presence of the targeting moiety on the properties of the nanoparticles. The insight provided by the study should provide a better understanding of the potential of NE as vehicles for drug delivery.

Identifier
DOI https://doi.org/10.5286/ISIS.E.61784894
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/61784894
Provenance
Creator Professor Jayne Lawrence; Ms Yuvared Luangwitchajaroen; Ms Orathai Loruthai; Dr Richard Heenan
Publisher ISIS Neutron and Muon Source
Publication Year 2018
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2015-06-07T08:00:00Z
Temporal Coverage End 2015-06-09T07:59:00Z