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Engineering nanoparticles for protein therapeutics - quantifying membrane acc...
The self-assembly properties of lipid systems can be exploited to form lipid membranes with complex morphologies. These include membranes with a lattice-type internal structure... -
Investigation of Folded Globular Maltose Binding Protein Based Hydrogels
We have developed a new model to describe the structural architecture of hydrogels composed of cross-linked maltose binding proteins (MBP), supported by multiple techniques... -
Probing bulk heterojunction (BHJ) thin films with graded morphologies using SANS
This projects aims to contribute to a better understanding of the relationship between processing conditions, active layer morphology and device performance in polymer solar... -
Folated derivatized nanoemulsions for the treatment of cancer
Nanoemulsions (NE) i.e. nanoparticles containing a fluid lipid or oil dispersed in water and stabilized by a surfactant particles have attracted considerable attention as... -
interaction of a pharmaceutical water-soluble polymer with bio-relevant surfa...
We have been developing hydroxypropylmethyl cellulose (HPMC) microspheres for delivering poorly water-soluble drugs. The in vitro dissolution data showed that the presence of... -
Small-Angle Neutron Scattering studies of a bacterial colonization factor
We plan to carry out SANS experiments on a bacterial colonization factor to elucidate how it interacts with chitin, which is found on the surface of plankton and crustaceans.... -
Surfactant induced gelation of TEMPO-oxidized cellulose; Using betaine-based ...
Our group has been working cellulose nanofibrils (OCNF) which form hydrogels in the presence of certain additives. Previously, we have studied the effect of salt, single... -
Structural Control of Microemulsion Droplets by Multiple-bridging Amphiphilic...
Microemulsions are thermodynamically stable, low-viscous liquid mixtures of oil and water stabilised by the presence of surfactant, structurally composed of oil-in-water (O/W)... -
Using SANS2D to resolve the opening of MscL clusters in proteoliposomes in re...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock. Although crucial for protecting cells, as with all ion channels, they have the... -
Solution structures of the immunologically important proteins IgA, IgG and C3
Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its... -
Architecture of lipid-protein nanoglobules in velvet worm prey capture slime
Fiber fabrication in animals is an important inspiration source for polymeric materials. Velvet worm prey capture slime represents a unique way of fiber fabrication by using... -
SANS Studies of Nanostructures of Microfluidically Fabricated lipid Nanoparti...
We have developed a new approach for forming lipid nanoparticles (LNP) with and without interfering RNA and DNA from a microfluidic setup. The LNPs are formed by an ionisable... -
Novel gels with supercritical carbon dioxide
This proposal is to probe the gel structure with High Pressure SANS (HP-SANS) using an in-line pressure cell. The ability to control the properties of supercritical CO2,... -
Self-assembly of polymer-stabilised cyclopeptide nanotubes
SANS will be used to determine the structure of nanotube dispersions formed by H-bond stacking of cyclopeptides coated with a sheath of stabilizing polymer. Cyclopeptide... -
Tuning the Molecular Exchange Kinetics of Self-Assembled Antimicrobial Peptid...
Self-assembling antimicrobial peptides (SAAMPs) are promising candidates for antibiotic substitutes. The self-assembled structure provides proteolytic stability to the... -
pH responsive Core-Shell-Corona (CSC) micellar complexes: Corona- and teleche...
Coacervation is an electrostatically-driven liquid-liquid phase separation process, resulting from the association of oppositely charged macro-ions. In this framework,... -
Using contrast matching to understand the networks in multicomponent systems
We have been focusing on two component gel networks. Here, both components can individually form gels. In a mixed system, the LMWG can either co-assemble or self-sort. In a... -
The effect of hydrophobic additives on low molecular weight gels
Low molecular weight gels are the result of the self-assembly of small molecules into fibres. These entangle to entrap the solvent. When the solvent is water, these are called... -
Bacterial lipoteichoic-acid (LTA) micelles: From molecular self-assembly to m...
Whilst the biological effect of lipoteichoic-acid (LTA) contributing to bacterial infections is widely reported in microbiological and immunological studies, very little is... -
Unlocking Structure-Property Relationships in Composite Semiconducting Nanopa...
Colloidal dispersions of organic semiconducting nanoparticles (NPs) have shown promise for the generation of active layers in organic solar cells.Composite NPs containing a...