Silk fibrillogenesis: Morphology, structure and hydration of the intermediate silk proteins

DOI

At the heart of protein¿s aggregation are specific molecular events; and how they are modulated by changes in solvent conditions is key to our understanding and control of fibrillogenesis. A certain class of structural fibrous proteins may provide the answer. Indeed, spider silk and silkworm silk proteins have evolved to readily form ¿insoluble¿ ordered structures. But, to date little is known about the series of association steps involved in the nucleation and growth of silk protofilaments. To characterise this process we must clearly establish the kinetics of silk fibril assembly and elongation. Therefore, we wish to follow the early events of fibrillogenesis by SANS and SAXS/WAXS to investigate the morphology, structures and hydration state of silk proteins intermediates.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24089318
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24089318
Provenance
Creator Dr Cedric Dicko; Dr Ann Terry; Mr Maxime Boulet-Audet; Professor Fritz Vollrath; Dr Imke Greving; Dr Christopher Holland
Publisher ISIS Neutron and Muon Source
Publication Year 2015
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2012-07-21T10:20:44Z
Temporal Coverage End 2012-10-22T09:53:48Z