Neutron reflectivity studies of the interaction between a novel antimicrobial agent and biomimetic lipid monolayers

DOI

A Unilever proprietary technology has been shown to inhibit biofilm growth and development, and is also found to possess antimicrobial activity, effective both as a broad-spectrum antibacterial and as an antifungal agent. This is unusual and requires both specific and holistic understanding of the agent’s mode of action at a molecular level. In the studies proposed here (performed using the technique of neutron reflectivity), we aim to determine the effect of this potential new drug on model fungal, bacterial and mammalian cell membranes. We hope then to elucidate the key common factors which render the technology effective in controlling biofilm formation as well as exploring the its impact on different infective organisms.

Identifier
DOI https://doi.org/10.5286/ISIS.E.98003933
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/98003933
Provenance
Creator Mr Xing Chen; Dr Delaram Ahmadi; Professor Jayne Lawrence; Dr Dave Barlow; Dr Farooq Malik; Dr Ian Tucker; Dr Mario Campana; Dr Fabrizia Foglia
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2018-10-18T08:00:00Z
Temporal Coverage End 2018-10-21T09:01:23Z