Structural and mechanistic study of nanocapsule / hydrogel composites for drug delivery applications

DOI

The targeted delivery of non-water soluble drugs for applications such as cancer remains a major challenge. Nanocapsules are new materials that can act as a depot for such drugs and release them in a controlled manner; however, they are difficult to keep in the location where drug delivery is desired. We are exploring the use of a fibrillar network, a self-assembled hydrogel, as promising means to act as a depot for the nanocapsules. While the hydrogel itself cannot control the release of the drug, it is able to 'trap' the nanocapsules and keep them at the site of action.While promising, this approach is relatively new and little is known about the interactions between nanocapsule and the hydrogel fibres. This work aims to gain critical insight into these interactions essential to the ability to design the composite material for optimised stability and drug delivery performance

Identifier
DOI https://doi.org/10.5286/ISIS.E.95670534
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/95670534
Provenance
Creator Mr Bhanu Teja Surikutchi; Dr Bin Yang; Professor Maria Alonso; Dr Mischa Zelzer; Dr Najet Mahmoudi; Dr Maria Marlow; Miss Maria Angelerou; Miss maria galini faidra angelerou
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2018-06-15T08:00:00Z
Temporal Coverage End 2018-06-18T08:58:12Z