SANS studies of Amphotec (aggregates of amphotericin-cholesteryl sulfate)

DOI

The anti-fungal agent amphotericin B (AmB) can be administered to patients in aqueous solution complexed with cholesteryl sulfate (CS), and this formulation helps to minimise the drug's side effects. Electron microscopy studies have shown that the AmB-CS aggregates are disks of ~115nm diameter, but their detailed architecture remains unknown. Such information, however, would be of significant benefit in the rational development of improved AmB formulations/delivery systems. It is the aim of the SANS studies proposed here to secure such information.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24079130
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24079130
Provenance
Creator Professor Jayne Lawrence; Dr Dave Barlow; Ms Fabrizia Foglia
Publisher ISIS Neutron and Muon Source
Publication Year 2012
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2009-12-08T09:03:21Z
Temporal Coverage End 2009-12-10T08:30:39Z