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Interplay of apoptosis regulating Bcl-2 proteins with mitochondrial membranes...
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a... -
Structure of the myoglobin-trehalose-water system
In this proposal we will study the structure of the myoglobin-trehalose-water system. It is well known that trehalose has an excellent cryo- and bioprotective role for... -
The action of membrane lytic compounds on model membranes.
The study of antifungal and antibacterial action is of great interest and there are still many unknowns concerning the action of membrane lytic materials, and the way that... -
Effects of Non-Steroid Anti-Inflammatory Drugs on the Microscopic Dynamics of...
Dioctadecyldimethylammonium bromide (DODAB), is a double chain synthetic cationic lipid that conforms the membrane-like bilayer structure and has found widespread use in several... -
Electrostatic Interactions between Floating Bilayers and Thiol Coated Interfa...
Bilayers which float below a self-assembled monolayer (SAM) coated solid support represent one of the most advanced membrane mimetics. Recently (RB 1720155) we assessed the... -
Unravelling the solution structures and stability of industrially-important a...
The glycosylation of glycoproteins is a major determinant of their stability, and glycans also affect their aggregatibility (precipitation). An understanding of this is... -
Differentiating structure-specific low-energy dynamics in tea-catechins
Tea-catechins differ in the molecular constitutions and stereochemistry, in-turn showing variance in their bioactivity and radical-scavenging potential. This evidences differing... -
Changes to the structure of natural lung surfactant following OH(aq) radical ...
The presence of lung surfactant at the air-water interface of the lung is vital to prevent alveolar collapse. Exposure to environmental pollutants can cause the formation of... -
Lipid bilayers suspended beneath the air/water interface for neutron reflecti...
Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,... -
Oral Delivery of Vaccines Using a Solid Phase Support and Enteric Coat
The effective oral delivery of vaccines represents one of the ¿holy grails¿ of drug delivery for reasons of 1) cost, 2) convenience and 3) patient compliance. However, the... -
Membrane-stacking Properties of Mutant Myelin Proteins
Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further... -
PROBING DRUG PHARMACODYNAMICS BY INS - THE EFFECT OF CISPLATIN-LIKE ANTICANCE...
Cancer is a growing health problem worldwide, and thus the development of effective chemotherapeutic approaches is crucial for improving human health. Much effort has been put... -
The structure of the Bam complex, the Gram-negative outer membrane protein fo...
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival, from providing basic physiological functions, to impairing virulence and... -
UCL ILDH cryoprotectant solution test
This dataset has no description
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Small angle neutron diffraction study of water re-crystallisation in solution...
Cryo-preservation is one of the most efficient methods used for storage and recovery of endangered species tissue for fertility treatment. Under low temperature conditions (~... -
Self-assembly of lipid and triblock copolymer-based amphiphiles for drug deli...
Soft self-assembled structures have been extensively used as drug nanocarriers. Their building blocks, naturally occurring and synthetic amphiphiles (lipids or block... -
Examination of Free Floating Models of the Gram-Negative Bacterial Outer Memb...
This dataset has no description
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Self-assembly of methyl ester sulfonate(MES) and sulfobetaine surfactant mixt...
The MES is representative of a promising group of anionic surfactants which have the potential for improved performance and biocompatibility / biosustainability, and their... -
Small-angle neutron scattering study of human growth hormone-surfactant compl...
Liquid pharmaceutical formulations are commonly comprised of proteins and surfactants, which interact in solution in order to provide an increase in system stability. Although... -
GISANS directed to study lipid bilayer structures on nanowire arrays
Nanowires are increasingly being used in life science to interact with living cells, for example as nanometer probes. The interaction between the cell membrane, i.e. a lipid...
