Changes to the structure of natural lung surfactant following OH(aq) radical initiated oxidation

DOI

The presence of lung surfactant at the air-water interface of the lung is vital to prevent alveolar collapse. Exposure to environmental pollutants can cause the formation of oxidising species within the aqueous phase that potentially damage the biophysical properties of the surfactant layer, with adverse health effects. We wish to study changes to the structure of natural (porcine) lung surfactant at the air-water interface when exposed to the aqueous phase oxidant OH. The results will complement our existing data from showing the damage caused by the gas phase oxidant ozone.

Identifier
DOI https://doi.org/10.5286/ISIS.E.RB1920563-1
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/110019118
Provenance
Creator Dr Rebecca Welbourn; Dr Thomas Arnold; Dr Katherine Thompson; Professor Martin King; Mr Tobias Robson
Publisher ISIS Neutron and Muon Source
Publication Year 2023
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2020-03-12T08:30:00Z
Temporal Coverage End 2020-03-16T08:30:00Z