Membrane-stacking Properties of Mutant Myelin Proteins

DOI

Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further characterized on the biomolecular scale. There are many myelin proteins that contribute to myelin membrane stacking and are involved in demyelinating diseases. We propose an experiment at the INTERneutron reflectometer, where the properties of these proteins can be investigated on supported stacked lipid bilayers. The proteins are disease mutant variants found in Charcot-Marie-Tooth neuropathy patients, . We started characterizing these proteins on INTER earlier this year, and the methods we use have been optimized before on SURF & D17 (ILL) reflectometers. We want to understand the impact of the mutations on the structural function of the protein. We therefore request an experiment of 5 days on the INTER reflectometer.

Identifier
DOI https://doi.org/10.5286/ISIS.E.96230170
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/96230170
Provenance
Creator Dr Mario Campana; Dr Arne Raasakka; Dr Petri Kursula; Miss Irantzu Yoldi; Dr Rob Barker
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2018-06-08T08:00:00Z
Temporal Coverage End 2018-06-28T13:16:47Z