Cyclic peptide-polymer conjugates can readily self-assembly into long nanotubes, and are being extensively studied for biomedical applications. Recently, we have conjugated a hydrophobic chain onto one side of the cyclic peptide (CP), and a hydrophilic chain on the other. Using SANS, we discovered that these structures self-assembled into large Janus-like structures, coined "tubisomes," with a hydrophobic core surrounded by CP-nanotubes and a hydrophilic shell. These make excellent candidates as trans-membrane pores, and drug/gene delivery vehicles. In the proposed study we will look at the pH induced self-assembly of these structures, where the hydrophobic shell consists of a pH-responsive polymer, as changing the pH will induce assemble/disassemble. By studying this closely we can pin down the fundamental parameters needed to control the assembly process to make bespoke structures.