The present project aims to achieve a more detailed structural characterization by SANS of Solid Lipid Nanoparticles (SLN) and liposomes in a perspective of an inhaled anti TB-therapy by means of DPI (dry powder inhaler) or MDI (metered dose inhaler) devices. This study will allow a deeper stuctural understanding of the placement/aggregation of rifampicin and isoniazid drugs into lipid vesicle carriers in order to reach a better knowledge of the encapsulation efficacy, stability into nanoparticles that strongly affects their antitubercular potentiality. These outcomes will be useful also for conceiving further co-loading experiments of two drugs in the same nanoparticle, which would allow a synergistic action after their local lung administration. Moreover, this analysis will provide us key information on the morphology of the lipid shell correlated to the loaded drug placement.