Contrast variation SANS to understand drug directed assembly of multi lamellar liposomes

DOI

Recurring infection following dental interventions such as fillings is the most common reason for failure, leading to further treatments including root canal therapy, where the infected dental pulp and root tissue is removed and replaced with an inert substance such as dental cement. Over half of root canal treatments still fail due to re-infection, leading to yet further treatment to remove the tooth. To address this problem, we have developed a series of antimicrobial liposomes, and seek to use neutron scattering to understand how incorporation of the drug affects the structure of the liposomes. We hope this will help to explain the differences in efficacy we have seen during our formulation development work, and accellerate progress in developoing formulations with different anytimicrobial drugs.

Identifier
DOI https://doi.org/10.5286/ISIS.E.99691631
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/99691631
Provenance
Creator Dr Alison Paul; Professor Alastair Sloan; Dr Elen Everett; Dr Steve King; Dr Craig James; Professor Rachel Errington
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2018-11-17T09:00:00Z
Temporal Coverage End 2018-11-19T09:15:22Z