14 datasets found

Hybrid lipid-polymer nanoparticles have demonstrated potential as drug delivery vehicles. The current proposal aims to use small angle neutron scattering (SANS) in combination...

The present proposal concerns a PEGylated, hydrophobic drug containing polylysine dendrimer that demonstrates unexplained batch-to-batch variability in that two batches of the...

We seek to develop hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patient compliance, decrease side effects and reduce dose and...

The genetic code of viruses is typically protected by a spherical protein container. This protein capsid is assembled from hundreds of individual proteins in a spontaneous...

The understanding the drug release mechanism from polymeric nanoparticles (PNPs) requires a detailed characterisation of the PNPs internal structure. Small-angle neutron...

Nanodiscs (NDs) are discoidal lipid-protein aggregates composed by a lipid bilayer surrounded by a protein belt. NDs are suitable systems to investigate membrane protein...

Surfactants are frequently used in personal care products to improve the wetting and oil solubilizing qualities of the products, which also leads to the skin irritation by...

This proposal combines small-angle neutron scattering with novel deuteration strategies to investigate amyloid protein fibrils. Variations in dynamics of elongation and breakage...

This study aims the micelle size and shape phase transition investigation for the amphiphilic drugs; adiphenine-HCl (antihistamine), amitriptyline-HCl (antidepressant), and...

The methyl ester sulfonate. MES, and ethyl ester sulfonate, EES, are representative of a promising group of anionic surfactants which have the potential for improved performance...

Recurring infection following dental interventions such as fillings is the most common reason for failure, leading to further treatments including root canal therapy, where the...

The process of cell division requires precise duplication of the genetic material. The separation of the two strands of DNA and the progression of the replisome are driven by...

At high pH many low molecular weight gelators (LMWG) are dispersed in solution. When a trigger is applied to lower the pH the gelator molecules self-assemble into one...

In the present study the acidic, anti-inflammatory drug, ibuprofen has been PEGylated using an polyoxyethylene chain of 750 molecular weight. The consequence of this PEGylation...