How does tendency to adopt different secondary structures from antimicrobial lipopeptides affect their membrane binding?

DOI

This work aims to exploit the unique capability of neutron reflection to examine how 2 antimicrobial lipopeptides that tend to adopt different secondary structures bind to model lipid membranes. Such structural features are sparsely available but are crucial to understanding how different antimicrobial peptides kill different microorganisms through membrane disruptions. Neutron reflection is about the only technique that can unravel the structural features that help us to distinguish the two antimicrobial peptides and link such structural information to antimicrobial behaviour. We request 4 days on Surf to complete this work.

Identifier
DOI https://doi.org/10.5286/ISIS.E.RB1910072-1
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/103215073
Provenance
Creator Professor Jian Lu; Dr Mario Campana; Mr KE FA; Dr Mingrui Liao; Mr Haoning Gong; Mr kangcheng shen
Publisher ISIS Neutron and Muon Source
Publication Year 2022
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Natural Sciences; Physics
Temporal Coverage Begin 2019-06-26T08:00:00Z
Temporal Coverage End 2019-07-03T10:22:57Z