Kinetics of Protein Adsorption on well-characterised polymer brushes

DOI

We wish to develop a rational understanding of the mechanisms underlying the way water soluble polymer brushes - in particular those of polyethylene oxide/polyethylene glycol - can resist protein adsorption and thus confer biocompatibility on surfaces. To do this, we need to study systematically the kinetics of protein adsorption on well-characterised PEO brushes as a function of brush molecular weight and grafting density. Our preliminary experiments have shown that we are in a position to prepare polymer brushes with good control over these parameters; now we need to complement laboratory based experiments using quartz-crystal microbalance and ellipsometry with neutron reflection experiments that will yield both the details of the brush segment length density profile and the precise nature of the interaction between the adsorbing protein molecule and the polymer brush.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24069168
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24069168
Provenance
Creator Professor Richard Jones; Dr Andrew Parnell; Mr Warren Taylor; Dr Mike Weir
Publisher ISIS Neutron and Muon Source
Publication Year 2012
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2009-06-10T10:32:50Z
Temporal Coverage End 2009-06-14T21:18:52Z