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Adsorption of modified polysorbate (Tween) surfactants at the air-water inter...
The nonionic polysorbate (Tween) surfactants are an important class of food grade surfactants. They are extensively use in emulsion and foam stabilisation, and are increasingly... -
Structural analysis of amino acyl-tRNA-dependent Ligation Reactions in Bacter...
Assembly of the peptidoglycan later of bacterial cell walls is a validated target for anti-bacterial agents: the late transpeptidation and transglycosylation steps are inhibited... -
Dynamics of proteins undergoing cold denaturation
Pressure as a variable in biophysics/biochemistry allow the structure/function and dynamics/function relationships to be analysed in detail in various biomolecular assemblies.... -
Biomolecular Cryoprotection in Deep Eutectic Solvents
Protecting biomolecules, such as proteins and enzymes, from the effects of cooling and freezing is important for the storage and handling of pharmaceuticals. Deep eutectic... -
Proton Zero Point Energy Effects on the Folding of Proteins
Earlier experiment at ISIS have shown that water responds to the distortion of the hydrogen bond network by delocalizing some of the protons in the vicinity of the defects. That... -
Dynamics of trehalose-glycerol and lysozyme/trehalose-glycerol mixtures
The proposed experiment aims to study the dynamics of trehalose/glycerol mixtures and lysozyme in presence of trehalose/glycerol mixtures at different relative concentration.... -
Simultaneous INS and Raman studies of lysozyme
The proposers have obtained a dispersive Raman spectrometer that is fibre optically coupled to a custom centrestick that will allow simultaneous Raman and neutron measurements.... -
Kinetics of Protein Adsorption on well-characterised polymer brushes
We wish to develop a rational understanding of the mechanisms underlying the way water soluble polymer brushes - in particular those of polyethylene oxide/polyethylene glycol -... -
Study of the bioprotective effectiveness of trehalose/glycerol mixtures on ly...
The proposed experiment aims to study the dynamics of hydrated lysozyme in presence of trehalose, glycerol and trehalose/glycerol mixtures at different relative concentration in... -
Biomolecular Cryoprotection in Deep Eutectic Solvents
Protecting biomolecules, such as proteins and enzymes, from the effects of cooling and freezing is important for the storage and handling of pharmaceuticals. Deep eutectic... -
Competitive and cooperative adsorption of lysozyme and human serum albumin
All solid surfaces in contact with biological systems form a protein corona and the nature of this corona determines the further response of the biosystem to that solid surface... -
Proteins of Different Size and Globular Stability Adsorbed at Oil/Water Inter...
In this work we explore how to use neutron reflection to study protein adsorption at the oil/water interface. Inter is preferred because we have built technical capability on... -
Proteins of Different Size and Globular Stability Adsorbed at Oil/Water Inter...
In this work we explore how to use neutron reflection to study protein adsorption at the oil/water interface. Inter is preferred because we have built technical capability on... -
Modes of protein adsorption at polyethylene oxide brushes of various polymer ...
We wish to understand the mechanism to which polymer brushes such as PEO resist the adsorption of protein and thus offer biocompatibility for various surface applications.... -
Kinetics of protein and protein mixture adsorption at the air/water interface
Many proteins exhibit a lag in lowering the surface tension at the air-water interface. The origin of this lag is not well understood either experimentally or theoretically. The... -
Modelling Protein-Protein Interactions and the Hofmeister Effect
Nimrod is a unique instrument that bridges atomic resolution solution scattering with small angle scattering. The opportunity therefore exists to probe both the microscopic... -
Study of the dynamics of lyophilized protein/bioprotectant systems
Developing recombinant protein pharmaceuticals has proved to be very challenging because of both the complexity of protein production and purification, and the limited physical... -
Study of the vibrational properties of homologous bioprotectant disaccharides...
The innovative research field on glass forming systems having bioprotective action has been originated from a growing demand from many biotechnological industrial research...