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Antibiotic Interactions with models of the Gram negative bacterial outer memb...
This dataset has no description
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Polymer-surfactant films containing glucose sensors
This proposal continues our research on mesostructured surfactant templated polymer films that form spontaneously at the air-water interface. Our recent research has shown it is... -
Confinement and Liquid Crystal Films
Liquid crystals (LCs) are known to act as good lubricants, however, the reason for this remains unclear. One contributing factor is thought to be the formation of ordered layers... -
The interpenetration of two poly(ethylene oxide) polymer brushes under confin...
Coating two surfaces with polymer brushes has been shown on many occasions to reduce friction by orders of magnitude. These ultra-low frictions are believed to stem from be the... -
Tuneable Adsorption of Soft Colloids on Model Biomembrane
Understanding how nanoparticles interact with lipid bilayers will potentially have high impact on the development of new drug delivery systems, and on the investigation of their... -
Protein exchange at the solid/liquid interface
The balance of proteins adsorbed at a surface is important in a wide range of situations, e.g. implants, nanoparticles. The accepted model is that rapidly diffusing proteins... -
Understanding the insertion of antibiotic toxins into the gram negative outer...
The gram-negative bacterial membrane is of extreme medical importance. Two of its major components are lipopolysaccharides (LPS's) and integral membrane proteins. Porins are... -
Spatially profiling internal microstructure changes during redox driven rapid...
The redox driven swelling and deswelling of conducting polymers has been termed Electronic Muscle actuation. One application of this property is as a sphincter-like valve in a... -
Seizing Membrane Proteins - Cytochrome P450 Reductase in Nanodiscs
This proposal seeks to shed light on the functional and structural characteristics of a specific membrane protein - cytochrome P450 reductase (abb. POR) - part of the cytochrome... -
Effect of membrane fluidity for novel dendrimer drug interaction and uptake m...
Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel... -
The effect of dendrimer surface functionalization on the interaction with mod...
Dendrimers are a unique class of nano-structured vehicles for drug and gene delivery into intracellular targets. Their surface chemistry influences their transport across... -
Extreme Synergistic mixing in Biosurfactant ionic surfactant mixtures
The biobased economy growing substantially and pressure to reduce reliance on palm and crude oil derived materials, demand that Home and Personal Care industries develops... -
Adsorbtion from nematic mixtures
The aim is to measure the preferential adsorption of one component in a nematic mixture. The base is 4-pentyl 4¿- cyanobiphenyl (5CB) and it is doped with 4-pentyl 4¿-... -
Multilayering of Methyl Ester Sulphonates at the Air-Aqueous Interface: Effec...
Surfactants usually form a single layer of molecules at the surface of water. We have shown that under certain conditions more than one layer may form. When this happens the... -
Investigating the Surface Structure of Ionic Liquid Mixtures using Neutron Re...
The structure of ionic liquid (IL)-gas interfaces is currently a hot topic in the field and understanding of the surface structure of pure ILs is improving. However, very little... -
Probing the effects of oxidative stress on the membrane binding of alpha-synu...
Neutron reflectometry will be used to characterise the cellular membrane binding interaction of alpha-synuclein under conditions mimicking oxidative stress. Alpha-synuclein is... -
Probing perfume surface delivery / retention rates in-situ
This proposal is part of a funded (CASE) project, aimed at understanding the delivery of benefit actives (perfumes) to interfaces and the development of new self-assembled... -
Charged nanogels and their ability to penetrate model lipid membranes
Drug delivery through the skin is an important route for administration of therapeutic agents. However, the outermost layer of the skin, the stratum corneum provides a... -
Further Studies on the Gating Mechanism of an Antimicrobial Peptide Using Con...
Antibiotic peptides are generally small, simple, usually alpha-helical peptides, which nevertheless show quite complex biological behaviour. We have been studying the gating... -
Adsorption and activity of Thermomyces lanuginosus Lipase (TLL) at the oilwat...
The purpose with the proposed project is to provide a better understanding of structural changes in interfacial lipid layers due action of lipolytic enzymes. In this study we...
