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Antibiotic Interactions with models of the Gram negative bacterial outer memb...
This dataset has no description
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Protein exchange at the solid/liquid interface
The balance of proteins adsorbed at a surface is important in a wide range of situations, e.g. implants, nanoparticles. The accepted model is that rapidly diffusing proteins... -
The effect of dendrimer surface functionalization on the interaction with mod...
Dendrimers are a unique class of nano-structured vehicles for drug and gene delivery into intracellular targets. Their surface chemistry influences their transport across... -
Does tethered PEG behave as a typical polymer brush at the solid-liquid inter...
We propose to make neutron reflectivity measurements of hydrophillic polymers covalently attached, via thiol chemistry, to the gold-water interface. In particular, we will... -
Charged nanogels and their ability to penetrate model lipid membranes
Drug delivery through the skin is an important route for administration of therapeutic agents. However, the outermost layer of the skin, the stratum corneum provides a... -
The Mechanism and Kinetics of Lipid Flip-Flop in Floating Phosphatidylcholine...
In order to maintain their asymmetric lipid distribution, cellular membranes have a number of means to translocate lipid molecules across the bilayer. On top of the well-studied... -
Effects of Architecture on Polymer Diffusion
As part of a wider study we are studying the effects of polymer architecture between cyclic and linear polymers. From ATR-FTIR measurements we observe clear differences between... -
Operando neutron reflectometry of of a crystalline silicon anode protected by...
Silicon electrodes for Li-batteries have a ten times higher gravimetric energy density than current electrodes. The major drawback is the big capacity fading associated with the... -
Neutron Reflection Studies on Adsorption of Myristoyl-L-Carnitine at the Air/...
The acyl-L-carnitines are a group of novel surfactants. Following our recent home laboratory work to synthesize, purify and characterize them, the aim of this proposal is to... -
Superconductivity and magnetism in Cu2+-based coordination polymer [Cu3C6S6]n
Cu-BHT exhibits perfect kagome lattice of Cu2+ and previous combined magnetization and specific heat results suggested the presence of strong spin fluctuations. If there are... -
Optimisation of Experimental Conditions for the Study of Anionic Self-Assembl...
We have developed a Self-assembled floating supported membrane sample system comprised of unsaturated phospholipid bilayers held ~1nm from a PEGylated charged alkane thiol SAM... -
Interaction between the bioactive lipopeptide fengycin and lipid membranes
One class of bioactive lipopeptides produced by Bacillus subtilis, fengycin, has strong surfaceactivity and interesting antifungal property with low hemolytic activityTo gain... -
Neutron Reflectometry of Tethered Microphase Separated Block Copolymers
Neutron reflectometry will be used to probe the scattering length density profile in tethered films of block copolymers grafted onto silicon substrates. The tethered... -
Separating static and dynamic contributions to the muon relaxation in Ca3(Co,...
Ca3CoMnO6 has alternating ions in ferromagnetic Ising chains that are antiferromagnetically coupled on a triangular lattice and realizes an important model in frustrated... -
Molecular architecture of monolayers formed by novel sterol-modified phosphol...
A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative... -
Reflectometry studies of the mechanism of formation of mesoporous silicate fi...
Surfactant-silica self-assembly processes have been extensively studied since the discovery of M41S mesoporous materials in 1992. Mesoporous silicate films can be grown from... -
Organisation of Outer membrane protein F at the air/liquid interface
Crystallisation of membrane proteins as a precursor to high resolution structural studies is a significant research bottleneck. We are investigating alternative methods to... -
The influence of transmembrane potential on the orientation of antimicrobial ...
Natural antimicrobials are of great interest, since they are antibiotics that act on the biological membrane, and it is believed that this makes it far more difficult for... -
Kinetics of Protein Adsorption on well-characterised polymer brushes
We wish to develop a rational understanding of the mechanisms underlying the way water soluble polymer brushes - in particular those of polyethylene oxide/polyethylene glycol -... -
Switchable adhesion between oppositely charged polyelectrolytes: dependence o...
Tuning the interactions between different surfaces has technological benefits in areas such as adhesion, compatibilisation and nano-actuators. We shall study the interaction...
