Probing chiral interactions in aqueous amino acid deriving polymers

DOI

Sodium deoxycholate (NaDC) is a low molecular weight gelator, widely known as one of the components of bile salts. Above a specific concentration, NaDC is able to form pH dependent chiral micelles. Whereas an increasing number of articles is dealing with NaDC hydrogel properties, an in-depth understanding of the chiral recognition between NaDC and enantiomeric polymers is still missing. In this proposal we wish to increase our knowledge on the ability of NaDC to selectively interact with chiral polymers, namely L- and D-ARGO7. These biobased polymers are synthesised by the polyaddition of L- or D-aminoacids to methylenebisacrylamide. In water, they showed conformations reminescent of the protein hairpin motif. Of interest is how NaDC micelles conformation changes upon addition of the charged polymer, and how the structure is differently affected by its D- or L- form.

Identifier
DOI https://doi.org/10.5286/ISIS.E.RB1910089-1
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/103213299
Provenance
Creator Professor Dame Elisabetta Ranucci; Miss Federica Lazzari; Dr Jenny Alongi; Dr Omar Mansour; Professor Peter Griffiths; Dr Robert Dalgliesh
Publisher ISIS Neutron and Muon Source
Publication Year 2022
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2019-07-12T23:00:00Z
Temporal Coverage End 2019-07-16T07:31:25Z