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The effect of polymer therapeutics on the structure of mucin solutions toward...
Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key... -
Understanding the spin-Peierls Transition in KTCNQ and derivatives
Motivated by work showing that magnetic coupling between TCNQ anions in potassium TCNQ (KTCNQ) can be changed simply by changing the aromatic substituents, we seek to qunatify... -
The search for ALC resonances in TRP-TYR: pioneering spatial and temporal res...
Electron transfer (ET) processes in peptides and proteins are key steps in the functioning of several natural enzymes including DNA photolyase and ribonucleitide reductase,... -
Examining the Structural Changes of a Central Nervous System Neurotransmitter...
GluR0 is a glutamate sensitive potassium ion channel from the cyanobacterium Synechocystis which has been identified via primary structural sequencing to be similar to... -
impact of mutlivalent counterions on surfactant adsorption
We request NR beam time on SURF to study the impact of multivalent counterions on the surface adsorption of alkyloxyethylene sulfate surfactants and alkyloxyethylene sulphate /... -
Controlling Biosurfactant self assembly in solution
Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce... -
Stabilising emulsions with protein-surfactant mixtures.
Hydrophobins, hfb2, are secreted fungal proteins, which are strongly surface active and possess powerful emulsion and foam stabilising properties. Understanding their... -
Interfacial / surface retention / delivery of perfumes from different surface...
This proposal is part of a funded (CASE) project, aimed at understanding the delivery of benefit actives (perfumes) to interfaces and the development of new self-assembled... -
Interactions between a polymer brush grown from a macro-initiator-modified sa...
We propose to make neutron reflectivity measurements of the weak polyelectrolyte, poly(dimethy amino ethyl methacrylate), grown from two different surface densities of initiator... -
Solution Aggregation of Short Peptide Amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly, leading interfacial adsorption and solution nano-aggregation.... -
Insertion of antimicrobial peptides into phospholipid monolayers at air/liqui...
We have designed a series of cationic peptides with different helix repeats that can kill bacteria but remain benign to mammalian host cells. The selectivity to cell types is... -
SANS Study of the interaction of model wax alcohols with non-ionic surfactant...
The understanding of the plant wax-surfactant interaction process is crucial to the development of more effective pesticide and fungicide formulations, essential for improving... -
Conformational changes on interaction of cytochrome c with lipid monolayers.
The main objective of the present work is to gain an understanding of the interaction of the cationic protein, cyt c with anionic lipid membranes. This objective will be... -
Adsorption of Organic Phosphate onto Silicon
This proposal presents to directly measure ¿bridging¿ of anionic surfactants on an anionic surface through multivalent ions from water under well-controlled conditions (pHs and... -
Adsorption kinetics from polymer/surfactant systems; PSS/CnTAB
Polymer-surfactant mixtures are widely used in commercial formulations in personal care, pharmaceutical and agrochemical, cleaning, automotive and food industries. The... -
Molecular interactions between phospholipid monolayers and dimethylsulphoxide
Neutron reflectivity will be employed to investigate the interaction between dimethylsulphoxide and monomolecular films of phosphatidylcholine. The monolayer will be used as a... -
Electrolyte induced self-assembly of methyl ester sulphonate surfactants
The addition of multivalent counterions (Al3+, Mg2+) induces multilayer adsorption of ionic surfactants at interfaces. It is associated with strong wetting conditions, invoking... -
Revealing the Structure behind the Synergistic Phase Behavior of the Ternary ...
The aim of this collaborative proposal is to unravel micro- and nano-structures underlying unusually high solution viscosities from mixed surfactant systems. SANS is a unique... -
Capture and isolation of radicals by green tea antioxidants
Molecular modelling suggests that the antioxidant molecule EGCG "folds up" around the radical it captures, and therefore should shield the spin density from the environment.... -
Structural characterisation of an electron-transfer protein, cytochrome c, on...
This proposal concerns the adsorption behaviour of an electron-transfer protein, cytochrome c, on modified electrode surfaces. Cytochrome c plays an important role in...