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Effect of pH on the complexation behaviour between Pluronic micelles, drugs a...
Pluronic micelles are attractive candidates as drug carriers. Despite the abundance of data on their association with various drugs, there is, in contrast, very little... -
Quantum dots with deuterated oleic acid shells and their functionalisation wi...
Our research aims to develop plastic films that change the colour of the light that passes through them, not by absorbing certain wavelengths of light, as a simple colour filter... -
Self-assembly of lipid and triblock copolymer-based amphiphiles for drug deli...
Soft self-assembled structures have been extensively used as drug nanocarriers. Their building blocks, naturally occurring and synthetic amphiphiles (lipids or block... -
Perfluorocarbon-loaded polymeric nanoparticles with multiple perfluorocarbon ...
Ultrasound is a very attractive and patient-friendly imaging technique, as it is easy to use, fast and non-invasive. Nevertheless, its use is severely limited by the low... -
Probing chiral interactions in aqueous amino acid deriving polymers
Sodium deoxycholate (NaDC) is a low molecular weight gelator, widely known as one of the components of bile salts. Above a specific concentration, NaDC is able to form pH... -
Self-assembly of GFP-HMPA protein polymer conjugates: Effect of polymer hydro...
Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation, crosslinking resulting in lack of orientation... -
Pickering emulsions stabilized with oxidised cellulose nanofibrils and starch
Our group has been working functionalised cellulose nanofibrils which form gels in aqueous formulations. Previously we have used these fibrils to stabilise oil-in-water... -
Novel materials for heat storage application: a small-angle neutron scatterin...
Large quantities of thermal energy can be stored reversibly in composite materials containing SrCl2 and Expanded Natural Graphite (ENG) upon exo-/endothermal ab-/desorption of... -
Modulating Tetronics self-assembly with cyclodextrins for drug delivery appli...
Amphiphilic linear surfactants based on PEO and PPO triblock copolymers, known as Pluronics, exhibit a rich polymorphism and have been extensively studied for their applications... -
Aggregate structures formed by lipopolysaccharide-peptide complexes in solution
Bacterial lipopolysaccharide (LPS) is a bioactive structural amphiphilic molecule which forms the outer leaflet of the outer membrane of the Gram negative cell envelope. During... -
interaction of a pharmaceutical water-soluble polymer with bio-relevant surfa...
We have been developing hydroxypropylmethyl cellulose (HPMC) microspheres for delivering poorly water-soluble drugs. The in vitro dissolution data showed that the presence of... -
Anion effects on self-assembly in deep eutectic solvents.
Deep Eutectic Solvents (DES) are mixtures of an organic salt with a hydrogen bond donor that form strong interactions which hinder crystallisation. DES share many features with... -
Effect of reversing lipid head group charge on vesicular properties
Zwitterionic lipids such as phosphatidylcholine (PC) are major components of the membranes that compartmentalize organisms. Although there is a large literature on PC, cationic... -
Structure of chain-grafted silica nanoparticles
The aim of the proposed experiment is to carry out a series of SANS measurements on chain-grafted silica nanoparticles prepared in our laboratory. In this experiment we plan to... -
FRET-based Conjugated Polymer Macromolecular Switch for Bio-Anion Recognition
We intend to study the aggregation behaviour of the all-conjugated block catiocopolyelectrolyte PF2/6-P3MAHT in the presence of the biomacroanion guanosine triphosphate (GTP) in... -
SANS study on the aggregation behavior of aza-crown-water soluble conjugated ...
Water-soluble conjugated polymers (WSCP) are an important class of materials which have received great attention as active materials in optoelectronic devices and in biosensing.... -
Designing polymer therapeutics to diffuse through mucin
Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key... -
Use of nitric oxide radicals for the formation of a supramolecular hydrogel
The aim of this proposal is to study the structure of hydrogel systems formed from fluorenylmethyloxycarbonyl (FMOC) protected peptides, via the use of nitric oxide radicals.... -
Solubilisation of Drug Molecules in Nonionic Surfactant Micelles: Structural ...
This proposal aims to understand how the structure of non-ionic surfactant micelles affects the amount of fungicides solubilised. SANS is a technique unique for unravelling the... -
Structure in Polymer Conetworks
This proposal is part of a new research programme at Reading which is focused on a new types of macromolecular structures namely conetworks and pseudo-conetworks. These are...