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Charged surfactant adsorption and detergency upon reconstituted plant cuticul...
A number of studies have determined that non-ionic surfactants are capable of altering diffusionrates and transportation of both water and active ingredients thorough the waxy... -
Neutron Reflection Studies on Adsorption of Lauroyl-L-Carnitine (C12-L-Caniti...
Acyl L-Carnitines are a group of novel surfactants with attractive physical and biological properties associated with their head group charge features. This work proposes to use... -
Controlling Biosurfactant self assembly in solution
Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce... -
Exploring CO2-philic/ CO2-phobic amphiphiles, cross-linkers and HC-polymers f...
Over the last two decades, many polymers have been tested to increase CO2 viscosity for applications in enhanced oil recovery using CO2 (CO2-EOR). Unfortunately, conventional... -
NR study of binding of short antimicrobial alpha-helix peptides with model li...
In this work we explore how our rationally designed peptide amphiphiles bind onto lipid monolayers using neutron reflection combined with deuterium labelling to the lipids,... -
Co-adsorption of monoclonal antibodies and non-ionic surfactants at the air/l...
Nonionic surfactants usually do not show affinity to proteins and they work via competitive surface and interfacial processes in a binary mixture with protein. However, we show... -
Surfactant mixtures in CO2
Studies by the Bristol group, and elsewhere [1, 2], have shown that highly branched hydrocarbon chains is the key factor for generating effective non-fluorous CO2 philic... -
The mechanism of lipid transport in Gram-negative bacteria
The bacterial cell envelope is one of the best targets for antimicrobial development. It is this envelope that harbours the instruments of microbial warfare, preventing its... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
Impact of multivalent counterions on surfactant self-assembly
We request SANS beam time on LOQ to study the impact of multivalent counterions on the micellisation of alkyloxyethylene sulfate surfactants and alkyloxyethylene sulphate /... -
Neutron reflection studies on model wax films reconstituted from chemicals
Morphological features of plant waxes vary from species to species, but little is understood about what controls these morphological changes although it is widely believed that... -
NR study of surface adsorption of antibodies with and without non-ionic surfa...
Nonionic surfactants usually do not show affinity to proteins and they work via competitive surface and interfacial processes in abinary mixture. However, we show in this work... -
Phase diagram of LAS molecule: SANS investigation into surfactant and lipid m...
This proposal would like SANS time to better understand the LAS phase diagram. This has been prompted by recent experiments which show the system is not fully understood under... -
Complex evolution of solution microstructure in LAS / nonionic surfactant mix...
This proposal is part of a broad programme of collaborative research between RAL / Oxford and Unilever, using predominantly scattering techniques to investigate the nature of... -
Manipulation of the aggregate curvature in water/dense CO2 system
This proposal aims to investigate how the curvature of surfactant assemblies in water/dense CO2 systems can be tuned via the design and mixing of CO2-phillic surfactants. One... -
Unusual structural change in geminis above the critical micelle concentration
gemini surfactants are essentially two surfactants joined by a linking chain. We have extensively explored cationic geminis at the air/water interface and they exhibit a range... -
The effect of phospholipid on the adsorption of HSA at a solid surface
As part of a project concerning the fate of nanoparticles in the body we have been studying the kinetic and competitive (or cooperative) aspects of protein adsorption. HSA is... -
Micelle formation from model surfactant binary and ternary compositions in th...
The effects of electrolytes on SLES3, C12E8 and LAS4 has been extensively studied, especially the effect on the critical micelle concentration of each surfactant. We wish to... -
Interactions between Designed Antimicrobial Lipopeptides and Inner Membrane L...
Neutron reflection will be used to reveal the structural changes from different inner membrane leaflet models upon interacting with a group of antimicrobial lipopeptides with... -
Novel dual purpose antimicrobials and co-formulates to regenerate currently r...
The increased prevalence of antimicrobial resistant bacteria is the most significant challenge facing the human-health today in both developed and developing worlds. It's...
